Analytical HPLC Method for Dorzolamide and Timolol Assay in Ophthalmic Solution: Development, Validation and Application for Drug Product Analysis

被引：0
|
作者：
Alvarez, Maria P. [1 ]
Genoud, Maria A. [1 ]
Saint Martin, Eduardo E. [1 ]
Gomez, Matias [1 ]
Spinetto, Marta [1 ]
机构：
[1] Adm Nacl Med Alimentos & Tecnol Med ANMAT, Inst Nacl Med, Av Caseros 2161, Buenos Aires, DF, Argentina
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2017年 / 36卷 / 04期
关键词：
dorzolamide; ophthalmic solution; timolol; validation;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This work describes the development and validation of an analytical HPLC method for dorzolamide hydrochloride and timolol maleate in ophthalmic solution. The aim of this research was to achieve a simple, linear, accurate, precise and robust method to be applied in the drug product analysis. At the end of work, the United Stated Pharmacopoeia already had its own encoded method, however, ours shows to be simpler than that, having the operational advantage of analyzing both active ingredients in the same chromatographic system.
引用
收藏
页码：658 / 664
页数：7
相关论文
共 50 条
  • [1] Analytical HPLC Method for Meprednisone Assay in Tablets: Development, Validation and Application for Drug Product Analysis
    Caputto, Maria E.
    Cancelada, Lucia B.
    Saint Martin, Eduardo
    Spinetto, Marta
    LATIN AMERICAN JOURNAL OF PHARMACY, 2015, 34 (01): : 169 - 176
  • [2] Analytical HPLC Method for Ketoconazole Assay in Tablets: Development, Validation and Application for Drug Product Analysis
    Saint Martin, Eduardo E.
    Saratsian, Ana K.
    Frino, Rocio M.
    Gomez, Matias E.
    Spinetto, Marta E.
    Nunez, Myriam
    Fernicola, Marcela
    LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 : 1163 - 1168
  • [3] Multivariate Optimization and Validation of a CE method for Simultaneous Analysis of Dorzolamide Hydrochloride and Timolol Maleate in Ophthalmic Solution
    Palabiyik, Ismail Murat
    Caglayan, Mehmet Gokhan
    Onur, Feyyaz
    CHROMATOGRAPHIA, 2011, 73 (5-6) : 541 - 548
  • [4] Multivariate Optimization and Validation of a CE method for Simultaneous Analysis of Dorzolamide Hydrochloride and Timolol Maleate in Ophthalmic Solution
    Ismail Murat Palabiyik
    Mehmet Gokhan Caglayan
    Feyyaz Onur
    Chromatographia, 2011, 73 : 541 - 548
  • [5] DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF BRINZOLAMIDE AND TIMOLOL BY HPLC FROM OPHTHALMIC PREPARATION
    Khatun, Rahima
    Islam, S. M. Ashraful
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2014, 5 (03): : 1001 - 1007
  • [6] New RP-HPLC Method Development and Validation for Dorzolamide in Ophthalmic Dosage Form
    Thangabalan, Boovizhikannan
    Kahsay, Getu
    Eticha, Tadele
    JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY, 2018, 2018
  • [7] Analytical Method Development and Validation of New RP-HPLC Method for Simultaneous Estimation of Brinzolamide and Timolol Maleate in Ophthalmic Solutions.
    Anusha, B.
    Susmita, A. Geetha
    Rajitha, G.
    RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2016, 7 (03): : 1290 - 1298
  • [8] Development and validation of HPLC analytical method for Nepafenac in ophthalmic dosage form (suspension)
    Usman, Shahnaz
    Akram, Muhammad
    Aziz, Asif
    Ramesh, Venkat
    Sarheed, Omar Abdulraheem
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2014, 27 (05) : 1541 - 1546
  • [9] Application of intelligent models and spectrophotometry method for simultaneous determination of Dorzolamide and Timolol in ophthalmic dosage form
    Valizadeh, Maryam
    Sohrabi, Mahmoud Reza
    Motiee, Fereshte
    OPTIK, 2020, 217
  • [10] Spectrochromatographic determination of dorzolamide hydrochloride and timolol maleate in an ophthalmic solution using three-way analysis methods
    Dinc, Erdal
    Buker, Eda
    TALANTA, 2019, 191 : 248 - 256
12345