Protective efficacy of heat-inactivated B. thailandensis, B. mallei or B. pseudomallei against experimental melioidosis and glanders

被引：43

作者：

Sarkar-Tyson, Mitali ^{[1
]}

Smither, Sophie J. ^{[1
]}

Harding, S. V. ^{[1
]}

Atkins, Timothy P. ^{[1
]}

Titball, Richard W. ^{[2
]}

机构：

[1] Def Sci & Technol Lab, Salisbury SP4 0JQ, Wilts, England

[2] Sch Biosci, Exeter EX4 4QD, Devon, England

来源：

VACCINE | 2009年 / 27卷 / 33期

关键词：

Burkholderia pseudomallei; Burkholderia mallei; Burkholderia thailandensis; Vaccine; Melioidosis; Glanders; BURKHOLDERIA-PSEUDOMALLEI; CAPSULAR POLYSACCHARIDE; MONOCLONAL-ANTIBODIES; MURINE MODEL; IMMUNITY; LIPOPOLYSACCHARIDE; IDENTIFICATION; RESPONSES; MUTANT; MICE;

D O I：

10.1016/j.vaccine.2009.05.040

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Burkholderia pseudomallei and Burkholderia mallei are gram-negative bacilli that are the causative agents of melioidosis and glanders, respectively. Both humans and animals are susceptible to both diseases. There is currently no vaccine available for the prevention of disease. We report the protective efficacy of heat-inactivated Burkholderia thailandensis, B. mallei or B. pseudomallei cells as vaccines against murine melioidosis and glanders. Immunisation with heat-inactivated B. pseudomallei cells provided the highest levels of protection against either melioidosis or glanders. These studies indicate the longer term potential for heat-inactivated bacteria to be developed as vaccines against melioidosis and glanders. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：4447 / 4451

页数：5

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