Tolling for Autoimmunity - Prime time for 7

被引：17

作者：

Marshak-Rothstein, Ann ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Microbiol, Boston, MA 02215 USA

来源：

IMMUNITY | 2006年 / 25卷 / 03期

关键词：

D O I：

10.1016/j.immuni.2006.08.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The reason certain self-antigens are consistently targeted by autoantibodies may be because they are self-adjuvants. Two papers in this issue of Immunity provide important insights into the contribution of Toll-like receptors in systemic autoimmune disease (Berland et al., 2006; Christensen et al., 2006).

引用

页码：397 / 399

页数：3

共 11 条

[1] Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice [J].

Berland, Robert ;

Fernandez, Luis ;

Kari, Elina ;

Han, Jin-Hwan ;

Lomakin, Ina ;

Akira, Shizuo ;

Wortis, Henry H. ;

Kearney, John F. ;

Ucci, Angelo A. ;

Imanishi-Kari, Thereza .

IMMUNITY, 2006, 25 (03) :429-440

[2] Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus [J].

Christensen, Sean R. ;

Shupe, Jonathan ;

Nickerson, Kevin ;

Kashgarian, Michael ;

Flavell, Richard A. ;

Shlomchik, Mark J. .

IMMUNITY, 2006, 25 (03) :417-428

[3] TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE [J].

Ehlers, M ;

Fukuyama, H ;

McGaha, TL ;

Aderem, A ;

Ravetch, JV .

JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (03) :553-561

[4] Innate immune recognition of nucleic acids: Beyond toll-like receptors [J].

Ishii, KJ ;

Akira, S .

INTERNATIONAL JOURNAL OF CANCER, 2005, 117 (04) :517-523

[5] Suppression of RNA recognition by Toll-like receptors:: The impact of nucleoside modification and the evolutionary origin of RNA [J].

Karikó, K ;

Buckstein, M ;

Ni, HP ;

Weissman, D .

IMMUNITY, 2005, 23 (02) :165-175

[6] Role of TLR9 in anti-nucleosome and anti-DNA antibody production in lpr mutation-induced murine lupus [J].

Lartigue, Aurelia ;

Courville, Philippe ;

Auquit, Isabelle ;

Francois, Arnaud ;

Arnoult, Christophe ;

Tron, Francois ;

Gilbert, Daniele ;

Musette, Philippe .

JOURNAL OF IMMUNOLOGY, 2006, 177 (02) :1349-1354

[7] Differential activation of anti-erythrocyte and anti-DNA autoreactive B lymphocytes by the Yaa mutation [J].

Moll, T ;

Martinez-Soria, E ;

Santiago-Raber, ML ;

Amano, H ;

Pihlgren-Bosch, M ;

Marinkovic, D ;

Izui, S .

JOURNAL OF IMMUNOLOGY, 2005, 174 (02) :702-709

[8]

Pisitkun P, 2006, SCIENCE, V312, P1669, DOI 10.1126/science.1124978

[9] A Tlr7 translocation accelerates systemic autoimmunity in murine lupus [J].

Subramanian, Srividya ;

Tus, Katalin ;

Li, Quan-Zhen ;

Wang, Andrew ;

Tian, Xiang-Hong ;

Zhou, Jinchun ;

Liang, Chaoying ;

Bartov, Guy ;

McDaniel, Lisa D. ;

Zhou, Xin J. ;

Schultz, Roger A. ;

Wakeland, Edward K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :9970-9975

[10] Toll-like receptor 9 signaling protects against murine lupus [J].

Wu, XB ;

Peng, SL .

ARTHRITIS AND RHEUMATISM, 2006, 54 (01) :336-342

← 1 2 →