Gene technology and tissue engineering

被引：2

作者：

Andree, C ^{[1
]}

Kullmer, M ^{[1
]}

Wenger, A ^{[1
]}

Schaefer, DJ ^{[1
]}

Kneser, U ^{[1
]}

Stark, GB ^{[1
]}

机构：

[1] Freiburg Univ Hosp, Dept Plast & Hand Surg, Freiburg, Germany

来源：

MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES | 2002年 / 11卷 / 03期

关键词：

gene transfer techniques; tissue engineering;

D O I：

10.1080/136457002320174159

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The interest in gene therapy to treat human diseases has increased with the advances in recombinant DNA technology and the improved physical, chemical and biological methods of delivering genes to mammalian cells. Areas of therapeutic interest for gene therapy relevant for tissue engineering are, for example, in the treatment of wounds, skin diseases, nerve, bone, and muscle diseases. The transfer of a gene into a cell can lead to the addition or modification of a function and may be an attractive alternative to the pharmacological use of proteins. The complementation of defective functions could also be an effective treatment for inherited skin diseases with a gene defect. The two major challenges facing gene technology in tissue engineering are the problem of identifying appropriate genes that are effective in tissue repair, and the reliable expression of the therapeutic gene at clinically beneficial levels. This review discusses principles and methods of delivering genes encoding growth factors into cells, together with their respective advantages and disadvantages.

引用

页码：93 / 99

页数：7

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