Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus

被引：419

作者：

Whitworth, Kristin M. ^{[1
]}

Rowland, Raymond R. R. ^{[2
]}

Ewen, Catherine L. ^{[2
]}

Trible, Benjamin R. ^{[2
]}

Kerrigan, Maureen A. ^{[2
]}

Cino-Ozuna, Ada G. ^{[2
]}

Samuel, Melissa S. ^{[1
]}

Lightner, Jonathan E. ^{[3
]}

McLaren, David G. ^{[3
]}

Mileham, Alan J. ^{[3
]}

Wells, Kevin D. ^{[1
]}

Prather, Randall S. ^{[1
]}

机构：

[1] Univ Missouri, Div Anim Sci, Columbia, MO USA

[2] Kansas State Univ, Dept Diagnost Med & Pathobiol, Manhattan, KS 66506 USA

[3] Genus Plc, De Forest, WI USA

来源：

NATURE BIOTECHNOLOGY | 2016年 / 34卷 / 01期

关键词：

SCAVENGER RECEPTOR CD163; SYNDROME PRRS; MACROPHAGES; HEMOGLOBIN; HAPTOGLOBIN; DISEASE;

D O I：

10.1038/nbt.3434

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：20 / 22

页数：3

共 18 条

[1] Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection [J].

Boddicker, Nicholas J. ;

Bjorkquist, Angelica ;

Rowland, Raymond R. R. ;

Lunney, Joan K. ;

Reecy, James M. ;

Dekkers, Jack C. M. .

GENETICS SELECTION EVOLUTION, 2014, 46

[2] CD163 and Inflammation: Biological, Diagnostic, and Therapeutic Aspects [J].

Etzerodt, Anders ;

Moestrup, Soren K. .

ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (17) :2352-2363

[3] Plasma Clearance of Hemoglobin and Haptoglobin in Mice and Effect of CD163 Gene Targeting Disruption [J].

Etzerodt, Anders ;

Kjolby, Mads ;

Nielsen, Marianne Jensby ;

Maniecki, Maciej ;

Svendsen, Pia ;

Moestrup, Soren Kragh .

ANTIOXIDANTS & REDOX SIGNALING, 2013, 18 (17) :2254-2263

[4] Targeting the Hemoglobin Scavenger receptor CD163 in Macrophages Highly Increases the Anti-inflammatory Potency of Dexamethasone [J].

Graversen, Jonas H. ;

Svendsen, Pia ;

Dagnaes-Hansen, Frederik ;

Dal, Jakob ;

Anton, Gabriele ;

Etzerodt, Anders ;

Petersen, Mikkel D. ;

Christensen, Peter A. ;

Moller, Holger J. ;

Moestrup, Soren K. .

MOLECULAR THERAPY, 2012, 20 (08) :1550-1558

[5]

Holtkamp DJ, 2013, J SWINE HEALTH PROD, V21, P72

[6]

Keffaber K., 1989, Am Assoc Swine Prac News, V1, P1

[7] ENHANCED REPLICATION OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS IN A HOMOGENEOUS SUBPOPULATION OF MA-104 CELL-LINE [J].

KIM, HS ;

KWANG, J ;

YOON, IJ ;

JOO, HS ;

FREY, ML .

ARCHIVES OF VIROLOGY, 1993, 133 (3-4) :477-483

[8] Pathogenicity of three type 2 porcine reproductive and respiratory syndrome virus strains in experimentally inoculated pregnant gilts [J].

Ladinig, Andrea ;

Detmer, Susan E. ;

Clarke, Kyle ;

Ashley, Carolyn ;

Rowland, Raymond R. R. ;

Lunney, Joan K. ;

Harding, John C. S. .

VIRUS RESEARCH, 2015, 203 :24-35

[9] Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China [J].

Li, Yufeng ;

Wang, Xinglong ;

Bo, Kuntao ;

Wang, Xianwei ;

Tang, Bo ;

Yang, Baoshou ;

Jiang, Wenining ;

Jiang, Ping .

VETERINARY JOURNAL, 2007, 174 (03) :577-584

[10] An Intact Sialoadhesin (Sn/SIGLEC1/CD169) Is Not Required for Attachment/Internalization of the Porcine Reproductive and Respiratory Syndrome Virus [J].

Prather, Randall S. ;

Rowland, Raymond R. R. ;

Ewen, Catherine ;

Trible, Benjamin ;

Kerrigan, Maureen ;

Bawa, Bhupinder ;

Teson, Jennifer M. ;

Mao, Jiude ;

Lee, Kiho ;

Samuel, Melissa S. ;

Whitworth, Kristin M. ;

Murphy, Clifton N. ;

Egen, Tina ;

Green, Jonathan A. .

JOURNAL OF VIROLOGY, 2013, 87 (17) :9538-9546

← 1 2 →