Long-term survival in a recipient of kidney transplant without maintenance immunosuppression: A case report

被引：2

作者：

Feng, Sujuan ^{[1
]}

Zhuang, Yuan ^{[2
]}

Liu, Hang ^{[1
]}

Zhang, Xiaodong ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Chao Yang Hosp, Inst Uronephrol, 8 Gong Ti Nan Lu, Beijing 100020, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Blood Transfus, Beijing 100853, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2018年 / 16卷 / 01期

基金：

中国博士后科学基金;

关键词：

kidney transplantation; immunosuppression; operational tolerance; RENAL-ALLOGRAFT TOLERANCE; REJECTION; THERAPY; CELLS;

D O I：

10.3892/etm.2018.6176

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Operational tolerance of an allograft kidney is the optimal condition in patients following kidney transplantation and recipient-mediated immunological rejection still remains the primary challenge following transplantation. In the present study, a case of long-term survival is reported in a patient following kidney transplantation without maintenance immunosuppression therapies for >10 years. Although the pathological conditions of the transplanted kidney revealed a degree of impaired kidney function, the patient exhibited a serum creatinine level of 119.2 mu mol/l and no significant changes were observed in T or B cell biomarkers associated with immunologic tolerance. Notably, the patient's allograft was functioning normally. Consequently, further studies may need to elucidate the development of operational tolerance.

引用

页码：360 / 363

页数：4

共 19 条

[1] ACTIVELY ACQUIRED TOLERANCE OF FOREIGN CELLS [J].

BILLINGHAM, RE ;

BRENT, L ;

MEDAWAR, PB .

NATURE, 1953, 172 (4379) :603-606

[2] Identification of a peripheral blood transcriptional biomarker panel associated with operational renal allograft tolerance [J].

Brouard, Sophie ;

Mansfield, Elaine ;

Braud, Christophe ;

Li, Li ;

Giral, Magali ;

Hsieh, Szu-Chuan ;

Baeten, Dominique ;

Zhang, Meixia ;

Ashton-Chess, Joanna ;

Braudeau, Cecile ;

Hsieh, Frank ;

Dupont, Alexandre ;

Pallier, Annaik ;

Moreau, Anne ;

Louis, Stephanie ;

Ruiz, Catherine ;

Salvatierra, Oscar ;

Soulillou, Jean-Paul ;

Sarwal, Minnie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (39) :15448-15453

[3] Circulating biomarkers of tolerance [J].

Girmanova, Eva ;

Hruba, Petra ;

Viklicky, Ondrej .

TRANSPLANTATION REVIEWS, 2015, 29 (02) :68-72

[4]

Glyda Maciej, 2011, Pol Przegl Chir, V83, P188, DOI 10.2478/v10035-011-0029-1

[5]

Heidt Sebastiaan, 2012, Expert Opin Med Diagn, V6, P281

[6] Long-Term Results in Recipients of Combined HLA-Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression [J].

Kawai, T. ;

Sachs, D. H. ;

Sprangers, B. ;

Spitzer, T. R. ;

Saidman, S. L. ;

Zorn, E. ;

Tolkoff-Rubin, N. ;

Preffer, F. ;

Crisalli, K. ;

Gao, B. ;

Wong, W. ;

Morris, H. ;

LoCascio, S. A. ;

Sayre, P. ;

Shonts, B. ;

Williams, W. W., Jr. ;

Smith, R. -N. ;

Colvin, R. B. ;

Sykes, M. ;

Cosimi, A. B. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (07) :1599-1611

[7] MIXED ALLOGENEIC CHIMERISM AND RENAL-ALLOGRAFT TOLERANCE IN CYNOMOLGUS MONKEYS [J].

KAWAI, T ;

COSIMI, AB ;

COLVIN, RB ;

POWELSON, J ;

EASON, J ;

KOZLOWSKI, T ;

SYKES, M ;

MONROY, R ;

TANAKA, M ;

SACHS, DH .

TRANSPLANTATION, 1995, 59 (02) :256-262

[8] Reconstitution of Peripheral Allospecific CD19+ B-Cell Subsets After B-Lymphocyte Depletion Therapy in Renal Transplant Patients [J].

Kopchaliiska, Dessislava ;

Zachary, Andrea A. ;

Montgomery, Robert A. ;

Leffell, Mary S. .

TRANSPLANTATION, 2009, 87 (09) :1394-1401

[9] Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance [J].

Krepsova, Eva ;

Tycova, Irena ;

Sekerkova, Alena ;

Wohlfahrt, Peter ;

Hruba, Petra ;

Striz, Ilja ;

Sawitzki, Birgit ;

Viklicky, Ondrej .

BMC NEPHROLOGY, 2015, 16

[10] Contrasting CD25hiCD4+T cells/FOXP3 patterns in chronic rejection and operational drug-free tolerance [J].

Louis, S ;

Braudeau, C ;

Giral, M ;

Dupont, A ;

Moizant, F ;

Robillard, N ;

Moreau, A ;

Soulillou, JP ;

Brouard, S .

TRANSPLANTATION, 2006, 81 (03) :398-407

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