Effect of varenicline on behavioral deficits in a rat model of Parkinson's disease induced by unilateral 6-hydroxydopamine lesion of substantia nigra

被引：5
作者：
Tan, Rueyal [1 ]
Bolukbasi Hatip, Funda [1 ]
Acikalin, Oznur [1 ]
Yamauchi, Atsushi [2 ]
Kataoka, Yasufumi [2 ]
Hatip-Al-Khatib, Izzettin [1 ]
机构：
[1] Pamukkale Univ, Dept Med Pharmacol, Fac Med, Denizli, Turkey
[2] Fukuoka Univ, Fac Pharmaceut Sci, Dept Pharmaceut Care & Hlth Sci, Fukuoka, Fukuoka, Japan
来源：
BEHAVIOURAL PHARMACOLOGY | 2018年 / 29卷 / 04期
关键词：
behavioral deficits; 6-hydroxydopamine; Parkinson's disease; rat; substantia nigra; varenicline; NICOTINIC ACETYLCHOLINE-RECEPTORS; DEEP BRAIN-STIMULATION; DOPAMINERGIC-NEURONS; SMOKING-CESSATION; PARTIAL AGONIST; MOTOR DEFICITS; STRIATUM; NUCLEUS; RELEASE; TOLERABILITY;
D O I：
10.1097/FBP.0000000000000355
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson's disease (PD). Varenicline tartrate is a partial agonist at 42 and full agonist at 7 neuronal nAChR subunits. A unilateral lesion of the substantia nigra (SN) has been used as a reliable model of PD. This study aimed to investigate the effect of varenicline on locomotor and nonlocomotor behavioral deficits induced by a unilateral lesion of the SN induced by 6-hydroxydopamine (6-OHDA) (8 mu g/4 mu l). Varenicline (1mg/kg) was administered to the lesioned rats daily for 2 weeks, which commenced 3 weeks after 6-OHDA administration. The results showed that varenicline improved motor deficits induced by 6-OHDA. It improved locomotor and nonlocomotor activities such as forelimb use, rotarod performance, and forelimb asymmetry. Varenicline did not change rearing or vibrissae-elicited forelimb placing but did increase apomorphine-induced rotation. In conclusion, the present results suggest that drugs with specific partial/full agonistic activity on nAChR subunits could be of value in the treatment of neurodegenerative disorders such as PD.
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收藏
页码：327 / 335
页数：9
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