The therapeutic role of 5-HT1A and 5-HT2A receptors in depression

被引：1
|
作者：
Celada, P [1 ]
Puig, MV [1 ]
Amargós-Bosch, M [1 ]
Adell, A [1 ]
Artigas, F [1 ]
机构：
[1] CSIC, Dept Neurochem, Inst Invest Biomed, Barcelona 08036, Spain
来源：
JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2004年 / 29卷 / 04期
关键词：
antidepressive agents; depression; dorsal raphe nucleus; gamma-aminobutyric acid; medial prefrontal cortex; microdialysis; pindolol; receptors; AMPA; serotonin; serotonin uptake inhibitors;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The selective serotonin reuptake inhibitors (SSRIs) are the most frequently prescribed antidepressant drugs, because they are well tolerated and have no severe side effects. They rapidly block serotonin (5-HT) reuptake, yet the onset of their therapeutic action requires weeks of treatment. This delay is the result of presynaptic and postsynaptic adaptive mechanisms secondary to reuptake inhibition. The prevention of a negative feedback mechanism operating at the 5-HT autoreceptor level enhances the neurochemical and clinical effects of SSRIs. The blockade of 5-HT2A receptors also seems to improve the clinical effects of SSRIs. These receptors are located postsynaptically to 5-HT axons, mainly in the neocortex. Pyramidal neurons in the prefrontal cortex are particularly enriched in 5-HT2A receptors. Their blockade may affect the function of prefrontal-subcortical circuits, an effect that probably underlies the beneficial effects of the addition of atypical antipsychotic drugs, which are 5-HT2A receptor antagonists, to SSRIs in treatment-resistant patients.
引用
收藏
页码：252 / 265
页数：14
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