The Morita-Baylis-Hillman Reaction: Advances and Contributions from Brazilian Chemistry

被引：24
|
作者：
Santos, Marilia S. [1 ]
Coelho, Fernando [1 ]
Lima-Junior, Claudio G. [2 ]
Vasconcellos, Mario L. A. A. [2 ]
机构：
[1] Univ Estadual Campinas, Dept Organ Chem, Inst Chem, Campinas, SP, Brazil
[2] Univ Fed Paraiba, Dept Chem, BR-58059900 Joao Pessoa, Paraiba, Brazil
来源：
CURRENT ORGANIC SYNTHESIS | 2015年 / 12卷 / 06期
基金：
巴西圣保罗研究基金会;
关键词：
Morita-Baylis-Hillman; Heterocycles; Drugs; Acrylates; Mass Spectrometry; Natural Products; ELECTROSPRAY-IONIZATION MASS; BETA-HYDROXY ESTERS; DIASTEREOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ALLYLIC THIOCYANATES; HIGHLY EFFICIENT; IONIC LIQUIDS; HECK REACTION; MECHANISM; ADDUCTS;
D O I：
10.2174/157017941206150828114416
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The Morita-Baylis-Hillman reaction is an organocatalyzed chemical transformation that allows access to small poly-functionalized molecules and has considerable synthetic potential and promising biological profiles. In this review, we report the efforts made by Brazilian research groups in recent years on the development of Morita-Baylis-Hillman chemistry. The review covers these contributions, with a focus on mechanistic studies, improvement of the experimental conditions, and the use of Morita-Baylis-Hillman adducts as building blocks for the synthesis of heterocycles, natural products and drugs.
引用
收藏
页码：830 / 852
页数：23
相关论文
共 50 条
  • [1] Recent Advances in the Morita-Baylis-Hillman Reaction Under Microwave Irradiation
    de Souza, Rodrigo O. M. A.
    Miranda, Leandro S. M.
    MINI-REVIEWS IN ORGANIC CHEMISTRY, 2010, 7 (03) : 212 - 220
  • [2] Sila Morita-Baylis-Hillman reaction of cyclopropenes
    Chuprakov, Stepan
    Malyshev, Denis A.
    Trofimov, Alexander
    Gevorgyan, Vladimir
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (48) : 14868 - 14869
  • [3] Nicholas cations in the Morita-Baylis-Hillman reaction
    Campbell, Mark
    Krafft, Marie E.
    Kerrigan, Sean
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [4] Recent extensions of the Morita-Baylis-Hillman reaction
    Ma, Guang-Ning
    Jiang, Jia-Jun
    Shi, Min
    Wei, Yin
    CHEMICAL COMMUNICATIONS, 2009, (37) : 5496 - 5514
  • [5] Recent Advances in Organocatalytic Asymmetric Morita-Baylis-Hillman/aza-Morita-Baylis-Hillman Reactions
    Wei, Yin
    Shi, Min
    CHEMICAL REVIEWS, 2013, 113 (08) : 6659 - 6690
  • [6] Recent advances in the annulation of Morita-Baylis-Hillman adducts
    Zhong, Neng-Jun
    Wang, Yi-Zhan
    Cheng, Liang
    Wang, Dong
    Liu, Li
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 16 (29) : 5214 - 5227
  • [7] Asymmetric organocatalytic Morita-Baylis-Hillman reaction and asymmetric organocatalytic transformations of Morita-Baylis-Hillman adducts. An update
    Pellissier, Helene
    TETRAHEDRON, 2025, 172
  • [8] Privileged chiral catalysts in asymmetric Morita-Baylis-Hillman/aza-Morita-Baylis-Hillman reaction
    Wei Yin
    Shi Min
    CHINESE SCIENCE BULLETIN, 2010, 55 (17): : 1699 - 1711
  • [9] Privileged chiral catalysts in asymmetric Morita-Baylis-Hillman/aza-Morita-Baylis-Hillman reaction
    WEI Yin SHI Min State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China
    Chinese Science Bulletin, 2010, 55 (17) : 1699 - 1711
  • [10] Recent Advances in Catalytic Systems for the Mechanistically Complex Morita-Baylis-Hillman Reaction
    Santos, Hugo
    Zeoly, Lucas A.
    Rodrigues Jr, Manoel T.
    Fernandes, Fabio S.
    Gomes, Ralph C.
    Almeida, Wanda P.
    Coelho, Fernando
    ACS CATALYSIS, 2023, 13 (06) : 3864 - 3895
12345