Saxagliptin/Dapagliflozin: A Review in Type 2 Diabetes Mellitus

被引：31

作者：

Garnock-Jones, Karly P. ^{[1
]}

机构：

[1] Springer, Private Bag 65901, Auckland 0754, New Zealand

来源：

DRUGS | 2017年 / 77卷 / 03期

关键词：

SAXAGLIPTIN PLUS DAPAGLIFLOZIN; DOUBLE-BLIND TRIAL; ADD-ON; COMBINATION THERAPY; TRIPLE THERAPY; BLADDER-CANCER; INHIBITOR PLUS; METFORMIN; MANAGEMENT; EFFICACY;

D O I：

10.1007/s40265-017-0697-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Saxagliptin/dapagliflozin fixed-dose combination tablets (Qtern (R)) are indicated in the EU for the improvement of glycaemic control in adults with type 2 diabetes mellitus (T2DM), either when treatment with metformin and/or a sulfonylurea plus a monocomponent of saxagliptin/dapagliflozin provides inadequate glycaemic control, or when the patient is already being treated with the free combination of saxagliptin + dapagliflozin. This narrative review summarizes pharmacological, efficacy and tolerability data relevant to the use of saxagliptin/dapagliflozin in this indication. The agents have complementary mechanisms of action, and saxagliptin/dapagliflozin fixed-dose combination tablets are bioequivalent to free combination of saxagliptin + dapagliflozin. In three phase III trials, saxagliptin + dapagliflozin + metformin was more effective at providing glycaemic control than saxagliptin + metformin or dapagliflozin + metformin in previously treated patients with T2DM and inadequate glycaemic control on metformin monotherapy or metformin plus one of the monocomponents. The combination is associated with decreased bodyweight and a low risk of hypoglycaemia. As the first dipeptidyl peptidase-4 (DPP-4) inhibitor/sodium-glucose co-transporter (SGLT2) inhibitor fixed-dose combination available in the EU for glycaemic control in patients with T2DM, saxagliptin/dapagliflozin is a useful new option in this setting.

引用

页码：319 / 330

页数：12

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