Studies on Antimicrobial Evaluation of Some 1-((1-(1H-Benzo[d]imidazol-2-yl)ethylidene)amino)-6-((arylidene)amino)-2-oxo-4-phenyl-1, 2-dihydropyridine-3,5-dicarbonitriles

被引：12

作者：

Desai, N. C. ^{[1
]}

Shihory, Niraj ^{[1
]}

Bhatt, Malay ^{[1
]}

Patel, Bonny ^{[1
]}

Karkar, Tushar ^{[1
]}

机构：

[1] Maharaja Krishnakumarsinhji Bhavnagar Univ, Dept Chem, Div Med Chem, Bhavnagar 364002, Gujarat, India

来源：

SYNTHETIC COMMUNICATIONS | 2015年 / 45卷 / 23期

关键词：

Benzimidazole; biological evaluation; MIC; 2-pyridone; ANTIFUNGAL ACTIVITY; ANTICANCER ACTIVITY; ANTIVIRAL ACTIVITY; BENZIMIDAZOLE; DERIVATIVES; ANTIBACTERIAL;

D O I：

10.1080/00397911.2015.1102286

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of 1-((1-(1H-benzo[d]imidazol-2-yl)ethylidene)amino)-6-((arylidene)amino)-2-oxo-4-phenyl-1,2-dihydropyridine-3,5-dicarbonitriles (4a-o) have been synthesized for the development of antimicrobial agents. Newly synthesized compounds were evaluated for their in vitro antibacterial activity against Gram-positive bacteria (Pseudomonas aeruginosa, Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli, Staphylococcus aureus), and antifungal activity (Candida albicans, Aspergillus niger, Aspergillus clavatus). These compounds were characterized by infrared, H-1 NMR, C-13 NMR, and mass spectra. The synthesized compounds 4b, 4e, 4h, and 4k showed potent antimicrobial activity against tested microorganisms.

引用

页码：2701 / 2711

页数：11

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