Atopic dermatitis physiopathology

被引：0
作者：
Waton, J. [1 ]
机构：
[1] Hop Brabois, Dept Dermatol & Allergol, Batiment Canton, F-54500 Vandoeuvre Les Nancy, France
来源：
ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE | 2017年 / 144卷
关键词：
Atopic dermatitis; Immunology; Epidermal barrier; Microbiota; Epigenetics; INNATE IMMUNE-RESPONSES; EPIDERMAL BARRIER; SKIN BARRIER; FILAGGRIN; PATHOGENESIS; KERATINOCYTES; EXPRESSION; DISEASE; CELLS; DYSREGULATION;
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Our understanding of the physiopathology of atopic dermatitis has much improved over the recent years. Epidermal barrier alterations are integrated into 2 theories called inside out and outside in. They are related to complex immune abnormalities. Understanding their mechanism makes it possible to foresee new therapeutics. Moreover, environmental biodiversity, the diversity of cutaneous microbiota and genetic predispositions in atopic dermatitis lead to a new, more comprehensive theory, "the biodiversity theory", integrating epigenetics. (C) 2017 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：S8 / S14
页数：7
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