Immune Checkpoint Blockade in Hepatocellular Carcinoma: Current Progress and Future Directions

被引：190
|
作者：
Hato, Tai [1 ]
Goyal, Lipika [2 ]
Greten, Tim F. [3 ]
Duda, Dan G. [1 ]
Zhu, Andrew X. [2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Ctr Canc, Dept Med, Boston, MA 02114 USA
[3] NCI, Gastrointestinal Malignancy Sect, Thorac & Gastrointestinal Oncol Branch, Bethesda, MD 20892 USA
来源：
HEPATOLOGY | 2014年 / 60卷 / 05期
基金：
美国国家卫生研究院;
关键词：
REGULATORY T-CELLS; PERCUTANEOUS ETHANOL INJECTION; SUPPRESSOR-CELLS; POSTOPERATIVE RECURRENCE; CTLA-4; BLOCKADE; LIVER; RESPONSES; PD-1; MOLECULES; HEPATITIS;
D O I：
10.1002/hep.27246
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Immune checkpoint blockade has recently emerged as a promising therapeutic approach for various malignancies including hepatocellular carcinoma (HCC). Preclinical and clinical studies have shown the potential benefit of modulating the immunogenicity of HCC. In addition, recent advances in tumor immunology have broadened our understanding of the complex mechanism of immune evasion. In this review we summarize the current knowledge on HCC immunology and discuss the potential of immune checkpoint blockade as a novel HCC therapy from the basic, translational, and clinical perspectives.
引用
收藏
页码：1776 / 1782
页数：7
相关论文
共 50 条
  • [1] Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma
    Yin, Xiaoqiang
    Wu, Tongchui
    Lan, Yadong
    Yang, Wulin
    BIOSCIENCE REPORTS, 2022, 42 (02)
  • [2] Optimizing radiotherapy with immune checkpoint blockade in hepatocellular carcinoma
    Choi, Changhoon
    Yoo, Gyu Sang
    Cho, Won Kyung
    Park, Hee Chul
    WORLD JOURNAL OF GASTROENTEROLOGY, 2019, 25 (20) : 2416 - 2429
  • [3] Current progress and prospect of immune checkpoint inhibitors in hepatocellular carcinoma
    Zeng, Zhu
    Yang, Biao
    Liao, Zheng-Yin
    ONCOLOGY LETTERS, 2020, 20 (04)
  • [4] The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review
    Pinter, Matthias
    Jain, Rakesh K.
    Duda, Dan G.
    JAMA ONCOLOGY, 2021, 7 (01) : 113 - 123
  • [5] Current Landscape of Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma
    Ruff, Samantha M.
    Manne, Ashish
    Cloyd, Jordan M.
    Dillhoff, Mary
    Ejaz, Aslam
    Pawlik, Timothy M.
    CURRENT ONCOLOGY, 2023, 30 (06) : 5863 - 5875
  • [6] Immune Checkpoint Blockade in Hepatocellular Carcinoma
    Kudo, M.
    LIVER CANCER, 2015, 4 (04) : 201 - 207
  • [7] Overview of Current Progress in Immune Checkpoint Inhibitor Therapy for Advanced Hepatocellular Carcinoma
    Dai, Xinlun
    Wang, Shupeng
    Niu, Chunyuan
    Ji, Bai
    Liu, Yahui
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2020, 19
  • [8] Immune checkpoint therapy-current perspectives and future directions
    Sharma, Padmanee
    Goswami, Sangeeta
    Raychaudhuri, Deblina
    Siddiqui, Bilal A.
    Singh, Pratishtha
    Nagarajan, Ashwat
    Liu, Jielin
    Subudhi, Sumit K.
    Poon, Candice
    Gant, Kristal L.
    Herbrich, Shelley M.
    Anandhan, Swetha
    Islam, Shajedul
    Amit, Moran
    Anandappa, Gayathri
    Allison, James P.
    CELL, 2023, 186 (08) : 1652 - 1669
  • [9] Immune checkpoint blockade for the treatment of human hepatocellular carcinoma
    Nishida, Naoshi
    Kudo, Masatoshi
    HEPATOLOGY RESEARCH, 2018, 48 (08) : 622 - 634
  • [10] Cure the Incurable? Recent Breakthroughs in Immune Checkpoint Blockade for Hepatocellular Carcinoma
    Chu, Pei-Yi
    Chan, Shih-Hsuan
    CANCERS, 2021, 13 (21)
12345