Synthesis of well-defined functional macromolecular chimeras based on poly(ethylene oxide) or poly(N-vinyl pyrrolidone)

被引：20

作者：

Karatzas, A. ^{[1
]}

Bilalis, P. ^{[1
]}

Iatrou, H. ^{[1
]}

Pitsikalis, M. ^{[1
]}

Hadjichristidis, N. ^{[1
]}

机构：

[1] Univ Athens, Dept Chem, Ind Chem Lab, Athens 15771, Greece

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2009年 / 69卷 / 07期

关键词：

Polypeptides; Poly(ethylene oxide); Poly(N-vinyl pyrrolidone); Ring opening polymerization; Nitroxide mediated radical polymerization; LIVING RADICAL POLYMERIZATION; BLOCK-COPOLYMERS; N-VINYLPYRROLIDONE; BIOMEDICAL APPLICATIONS; ANIONIC-POLYMERIZATION; DIBLOCK COPOLYMERS; AQUEOUS-SOLUTIONS; MOLECULAR-WEIGHT; POLYPEPTIDES; CHEMISTRY;

D O I：

10.1016/j.reactfunctpolym.2008.12.003

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

By using either NH2-functionalized linear/4-arm star poly(ethylene oxide) or NH2-TEMPO initiator, the following novel polymer/polypeptide hybrids (macromolecular chimeras) of poly(ethylene oxide), PEO and poly(N-vinyl pyrrolidone), PNVP, were synthesized: PEO-b-(PBLG or PBLL), PEO-b-PBLL-b-PBLG, 4-arm star copolymer (PEO-b-PBLG)(4), PNVP-b-PBLG-b-PBLL, where PBLG is poly(gamma-benzyl-L-glutamate) and PBLL, poly(tert-butyloxycarbonyl-L-lysine). The amino-groups are used for the ring opening polymerization (ROP) of alpha-amino acid carboxyanhydrides (NCAs), while TEMPO was employed for the polymerization of NVP. Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based on the recently developed living ROP of NCAs and controlled/living TEMPO polymerization, using high vacuum techniques. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：435 / 440

页数：6

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