Helicobacter pylori in Health and Disease

被引：585

作者：

Cover, Timothy L. ^{[1
,2
,3
]}

Blaser, Martin J. ^{[4
]}

机构：

[1] Vanderbilt Univ, Sch Med, Div Infect Dis, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

[3] Vet Affairs Tennessee Valley Healthcare Syst, Nashville, TN USA

[4] NYU, Sch Med, Dept Med, New York, NY USA

来源：

GASTROENTEROLOGY | 2009年 / 136卷 / 06期

基金：

美国国家卫生研究院;

关键词：

CAG PATHOGENICITY ISLAND; GASTRIC EPITHELIAL-CELLS; MEMBRANE CHANNEL FORMATION; VACUOLATING TOXIN VACA; CYTOCHROME-C RELEASE; CAMPYLOBACTER-PYLORI; BIOLOGICAL-ACTIVITY; CLINICAL-RELEVANCE; VIRULENCE FACTORS; T-LYMPHOCYTE;

D O I：

10.1053/j.gastro.2009.01.073

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Helicobacter pylori is highly adapted for colonization of the human stomach and is present in about half of the human population. When present, H pylori is usually the numerically dominant gastric microorganism. H pylori typically does not cause any adverse effects, but it is associated with an increased risk of noncardia gastric adenocarcinoma, gastric lymphoma, and peptic ulcer. Disorders such as esophageal diseases and childhood-onset asthma were recently reported to occur more frequently in individuals who lack H pylori than in H pylori-positive persons. In this review, we discuss biologic factors that allow H pylori to colonize the human stomach, mechanisms by which H pylori increases the risk of peptic ulcer disease and noncardia gastric adenocarcinoma, and potential benefits that H pylori might confer to humans.

引用

页码：1863 / 1873

页数：11

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