Broflanilide: A meta-diamide insecticide with a novel mode of action

被引：152

作者：

Nakao, Toshifumi ^{[1
]}

Banba, Shinichi ^{[1
]}

机构：

[1] Mitsui Chem Agro Inc, Agrochem Res Ctr, Mobara, Chiba 2970017, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2016年 / 24卷 / 03期

关键词：

A2 ' mutation; Broflanilide; Insecticide; Meta-diamide; RDL GABA receptor; RDL GABA RECEPTOR; GAMMA-AMINOBUTYRIC-ACID; CONVENTIONAL NONCOMPETITIVE ANTAGONISTS; SOGATELLA-FURCIFERA; FIPRONIL RESISTANCE; MOLECULAR-CLONING; A2'N MUTATION; BINDING; SITE; MECHANISMS;

D O I：

10.1016/j.bmc.2015.08.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Broflanilide is a meta-diamide [3-benzamido-N-(4-(perfluoropropan-2-yl) phenyl) benzamide] that exhibits high larvicidal activity against Spodoptera litura. It has been suggested that broflanilide is metabolized to desmethyl-broflanilide and that it acts as a noncompetitive resistant-to-dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor antagonist. The binding site of desmethyl-broflanilide was demonstrated to be distinct from that of conventional noncompetitive antagonists such as fipronil. It has been proposed that the site of action for desmethyl-broflanilide is close to G336 in the M3 region of the Drosophila RDL GABA receptor. However, although the site of action for desmethyl-broflanilide appears to overlap with that of macrocyclic lactones, different modes of actions have been demonstrated for desmethyl-broflanilide and the macrocyclic lactones. The mechanisms underlying the high selectivity of meta-diamides are also discussed in this review. Broflanilide is expected to become a prominent insecticide because it is effective against pests with resistance to cyclodienes and fipronil. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：372 / 377

页数：6

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