Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map

被引：305

作者：

Yu, CR ^{[1
]}

Power, J

Barnea, G

O'Donnell, S

Brown, HE

Osborne, J

Axel, R

Gogos, JA

机构：

[1] Columbia Univ, Ctr Neurobiol & Behav, New York, NY 10032 USA

[2] Columbia Univ, Dept Anat & Cell Biol, New York, NY 10032 USA

[3] Columbia Univ, Dept Biochem & Mol Biophys, New York, NY 10032 USA

[4] Columbia Univ, Howard Hughes Med Inst, New York, NY 10032 USA

[5] Columbia Univ, Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York, NY 10032 USA

来源：

NEURON | 2004年 / 42卷 / 04期

关键词：

D O I：

10.1016/S0896-6273(04)00224-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have developed a genetic approach to examine the role of spontaneous activity and synaptic release in the establishment and maintenance of an olfactory sensory map. Conditional expression of tetanus toxin light chain, a molecule that inhibits synaptic release, does not perturb targeting during development, but neurons that express this molecule in a competitive environment fail to maintain appropriate synaptic connections and disappear. Overexpression of the inward rectifying potassium channel, Kir2.1, diminishes the excitability of sensory neurons and more severely disrupts the formation of an olfactory map. These studies suggest that spontaneous neural activity is required for the establishment and maintenance of the precise connectivity inherent in an olfactory sensory map.

引用

页码：553 / 566

页数：14

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