Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group

被引：488

作者：

Kelly, S. ^{[1
,2
]}

Jahanshad, N. ^{[1
]}

Zalesky, A. ^{[3
,4
]}

Kochunov, P. ^{[5
]}

Agartz, I. ^{[6
,7
,8
,9
]}

Alloza, C. ^{[10
]}

Andreassen, O. A. ^{[11
]}

Arango, C. ^{[12
]}

Banaj, N. ^{[13
]}

Bouix, S. ^{[14
]}

Bousman, C. A. ^{[3
,4
,15
,16
,17
]}

Brouwer, R. M. ^{[18
]}

Bruggemann, J. ^{[19
,20
]}

Bustillo, J. ^{[21
]}

Cahn, W. ^{[18
]}

Calhoun, V. ^{[22
,23
]}

Cannon, D. ^{[24
]}

Carr, V. ^{[19
,20
]}

Catts, S. ^{[25
]}

Chen, J. ^{[26
,27
]}

Chen, J-X ^{[27
]}

Chen, X. ^{[28
]}

Chiapponi, C. ^{[29
]}

Cho, Kl K. ^{[30
]}

Ciullo, V. ^{[13
]}

Corvin, A. S. ^{[31
,32
]}

Crespo-Facorro, B. ^{[33
,34
]}

Cropley, V. ^{[3
,4
]}

De Rossi, P. ^{[13
,35
,36
]}

Diaz-Caneja, C. M. ^{[12
]}

Dickie, E. W. ^{[37
]}

Ehrlich, S. ^{[38
]}

Fan, F-M ^{[27
]}

Faskowitz, J. ^{[1
]}

Fatouros-Bergman, H. ^{[8
]}

Flyckt, L. ^{[39
,40
,41
]}

Ford, J. M. ^{[42
]}

Fouche, J-P ^{[43
]}

Fukunaga, M. ^{[44
]}

Gill, M. ^{[31
,32
]}

Glahn, D. C. ^{[45
,46
]}

Gollub, R. ^{[2
,47
,48
]}

Goudzwaard, E. D. ^{[49
]}

Guo, H. ^{[50
]}

Gur, R. E. ^{[51
]}

Gur, R. C. ^{[51
]}

Gurholt, T. P. ^{[6
,7
]}

Hashimoto, R. ^{[52
,53
]}

Hatton, S. N. ^{[54
]}

Henskens, F. A. ^{[55
,56
,57
]}

机构：

[1] Univ Southern Calif, Keck Sch Med, Imaging Genet Ctr, Stevens Neuroimaging & Informat Inst, Marina Del Rey, CA 90292 USA

[2] Harvard Med Sch, Boston, MA USA

[3] Univ Melbourne, Melbourne Neuropsychiat Ctr, Dept Psychiat, Carlton, Vic, Australia

[4] Melbourne Hlth, Carlton, Vic, Australia

[5] Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA

[6] Univ Oslo, Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT,KG Jebsen Ctr Psychosis Res, Oslo, Norway

[7] Univ Oslo, Inst Clin Med, Oslo, Norway

[8] Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden

[9] Diakonhjemmet Hosp, Dept Psychiat Res, Oslo, Norway

[10] Univ Edinburgh, Edinburgh, Midlothian, Scotland

[11] Univ Oslo, Oslo, Norway

[12] Univ Complutense, Child & Adolescent Psychiat Dept, Hosp Gen Univ Gregorio Maranon, Sch Med,IiSGM,CIBERSAM, Madrid, Spain

[13] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome, Italy

[14] Harvard Med Sch, Brigham & Womens Hosp, Dept Psychiat, Boston, MA USA

[15] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[16] Univ Melbourne, Dept Gen Practice, Parkville, Vic, Australia

[17] Swinburne Univ Technol, Melbourne, Vic, Australia

[18] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Psychiat, Utrecht, Netherlands

[19] Neurosci Res Australia, Sydney, NSW, Australia

[20] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[21] Univ New Mexico, Albuquerque, NM 87131 USA

[22] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA

[23] Mind Res Network, Albuquerque, NM USA

[24] Natl Univ Ireland Galway, NCBES Galway Neurosci Ctr, Clin Neuroimaging Lab, Ctr Neuroimaging & Cognit Genom NICOG, Galway, Ireland

[25] Univ Queensland, Sch Med, Discipline Psychiat, Herston, Qld, Australia

[26] Ohio State Univ, Dept Comp Sci & Engn, Columbus, OH 43210 USA

[27] Beijing Huilongguan Hosp, Beijing, Peoples R China

[28] Pfizer, Worldwide Res & Dev, Cambridge, MA USA

[29] Santa Lucia Fdn, Rome, Italy

[30] Seoul Natl Univ, Dept Psychiat, Coll Med, Seoul, South Korea

[31] Trinity Coll Dublin, Dept Psychiat, Inst Mol Med, Dublin, Ireland

[32] Trinity Coll Dublin, Neuropsychiat Genet Res Grp, Inst Mol Med, Dublin, Ireland

[33] Univ Cantabria, Sch Med, Univ Hosp Marques de Valdecilla, IDIVAL,Dept Med & Psychiat, Santander, Spain

[34] CIBERSAM, Santander, Spain

[35] Univ Sapienza Rome, Fac Med & Psychol, Dept NESMOS, Rome, Italy

[36] Sapienza Univ Rome, Dept Neurol & Psychiat, Rome, Italy

[37] Ctr Addict & Mental Hlth, Toronto, ON, Canada

[38] Tech Univ Dresden, Univ Hosp CG Carus, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany

[39] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia

[40] Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia

[41] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia

[42] Univ Calif San Francisco, VAMC, San Francisco, CA 94143 USA

[43] Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa

[44] Natl Inst Physiol Sci, Div Cerebral Integrat, Aichi, Japan

[45] Yale Univ, Sch Med, Olin Neuropsychiat Res Ctr, Inst Living,Hartford Hosp, New Haven, CT USA

[46] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

[47] Harvard Med Sch, Massachusetts Gen Hosp, Dept Psychiat, Boston, MA USA

[48] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA USA

[49] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA

[50] Zhumadian Psychiat Hosp, Zhumadian, Henan, Peoples R China

来源：

MOLECULAR PSYCHIATRY | 2018年 / 23卷 / 05期

基金：

欧洲研究理事会; 英国医学研究理事会;

关键词：

FRACTIONAL ANISOTROPY; CORPUS-CALLOSUM; ANTERIOR COMMISSURE; SPATIAL STATISTICS; INTERNAL CAPSULE; BRAIN; CONNECTIVITY; REGISTRATION; SIZE; ABNORMALITIES;

D O I：

10.1038/mp.2017.170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely between studies. In an effort to identify commonalities across studies, we perform what we believe is the first ever large-scale coordinated study of WM microstructural differences in schizophrenia. Our analysis consisted of 2359 healthy controls and 1963 schizophrenia patients from 29 independent international studies; we harmonized the processing and statistical analyses of diffusion tensor imaging (DTI) data across sites and meta-analyzed effects across studies. Significant reductions in fractional anisotropy (FA) in schizophrenia patients were widespread, and detected in 20 of 25 regions of interest within a WM skeleton representing all major WM fasciculi. Effect sizes varied by region, peaking at (d = 0.42) for the entire WM skeleton, driven more by peripheral areas as opposed to the core WM where regions of interest were defined. The anterior corona radiata (d= 0.40) and corpus callosum (d = 0.39), specifically its body (d = 0.39) and genu (d = 0.37), showed greatest effects. Significant decreases, to lesser degrees, were observed in almost all regions analyzed. Larger effect sizes were observed for FA than diffusivity measures; significantly higher mean and radial diffusivity was observed for schizophrenia patients compared with controls. No significant effects of age at onset of schizophrenia or medication dosage were detected. As the largest coordinated analysis of WM differences in a psychiatric disorder to date, the present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.

引用

页码：1261 / 1269

页数：9

共 57 条

[1] Reproducibility of tract-based white matter microstructural measures using the ENIGMA-DTI protocol [J].