Repeated cocaine injections have no influence on tyrosine hydroxylase activity in the rat nucleus accumbens core or shell

被引:10
作者
Licata, SC
Pierce, RC
机构
[1] Boston Univ, Sch Med, Dept Pharmacol, Lab Neuropsychol Pharmacol, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Dept Psychiat, Lab Neuropsychol Pharmacol, Boston, MA 02118 USA
关键词
cocaine; microdialysis; DOPA; tyrosine hydroxylase; nucleus accumbens; rat;
D O I
10.1016/j.brainres.2004.03.043
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Numerous reports have demonstrated augmented cocaine-evoked release of dopamine in the nucleus accumbens of rats pre-treated with cocaine. However, the extent to which repeated cocaine injections affect basal levels of dopamine is unclear. There have been reports of increases, decreases, or no change in basal levels of extracellular accumbal dopamine resulting from repeated psychostimulant administration. The present study assessed the activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, in the nucleus accumbens following either acute or repeated cocaine administration. The in vivo microdialysis technique was used to measure accumulation of the dopamine precursor DOPA following intra-accumbal administration of the DOPA decarboxylase inhibitor NSD 1015 through the microdialysis probe. This method provides an estimate of tyrosine hydroxylase activity within the nucleus accumbens. Results indicate that neither acute nor repeated cocaine administration produced any change in DOPA accumulation in either the nucleus accumbens shell or core. These data indicate that dopamine synthesis is not altered by cocaine administration. (C) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:119 / 126
页数:8
相关论文
共 51 条
  • [41] The dopamine hypothesis of reward: past and current status
    Spanagel, R
    Weiss, F
    [J]. TRENDS IN NEUROSCIENCES, 1999, 22 (11) : 521 - 527
  • [42] Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
    Thomas, MJ
    Beurrier, C
    Bonci, A
    Malenka, RC
    [J]. NATURE NEUROSCIENCE, 2001, 4 (12) : 1217 - 1223
  • [43] Repeated cocaine treatment alters tyrosine hydroxylase in the rat nucleus accumbens
    Todtenkopf, MS
    De Leon, KR
    Stellar, JR
    [J]. BRAIN RESEARCH BULLETIN, 2000, 52 (05) : 407 - 411
  • [44] Dopaminergic mechanisms mediating the long-term expression of locomotor sensitization following pre-exposure to morphine or amphetamine
    Vanderschuren, LJMJ
    Schoffelmeer, ANM
    Mulder, AH
    De Vries, TJ
    [J]. PSYCHOPHARMACOLOGY, 1999, 143 (03) : 244 - 253
  • [45] WEISS F, 1992, J NEUROSCI, V12, P4372
  • [46] USE OF MICRODIALYSIS FOR MONITORING TYROSINE-HYDROXYLASE ACTIVITY IN THE BRAIN OF CONSCIOUS RATS
    WESTERINK, BHC
    DEVRIES, JB
    DURAN, R
    [J]. JOURNAL OF NEUROCHEMISTRY, 1990, 54 (02) : 381 - 387
  • [47] INCREASED LEVER PRESSING FOR AMPHETAMINE AFTER PIMOZIDE IN RATS - IMPLICATIONS FOR A DOPAMINE THEORY OF REWARD
    YOKEL, RA
    WISE, RA
    [J]. SCIENCE, 1975, 187 (4176) : 547 - 549
  • [48] ON THE SIGNIFICANCE OF SUBTERRITORIES IN THE ACCUMBENS PART OF THE RAT VENTRAL STRIATUM
    ZAHM, DS
    BROG, JS
    [J]. NEUROSCIENCE, 1992, 50 (04) : 751 - 767
  • [49] Zhang JH, 2002, ANN NY ACAD SCI, V965, P1
  • [50] Repeated cocaine treatment decreases whole-cell calcium current in rat nucleus accumbens neurons
    Zhang, XF
    Cooper, DC
    White, FJ
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 301 (03) : 1119 - 1125