Current understanding of the genetic diversity of Mycobacterium avium subsp paratuberculosis

被引：49
作者：
Motiwala, Alifiya S.
Li, Lingling
Kapur, Vivek
Sreevatsan, Srinand
机构：
[1] Univ Minnesota, Dept Microbiol, St Paul, MN 55108 USA
[2] Univ Minnesota, Biomed Genom Ctr, St Paul, MN 55108 USA
[3] Ohio State Univ, Ohio Agr Res & Dev Ctr, Food Anim Hlth Res Program, Wooster, OH 44691 USA
[4] Ohio State Univ, Dept Vet Prevent Med, Wooster, OH 44691 USA
来源：
MICROBES AND INFECTION | 2006年 / 8卷 / 05期
关键词：
amplified fragment length polymorphism; Johne's disease; diversity; genotyping; Crohn's disease;
D O I：
10.1016/j.micinf.2005.12.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed. (c) 2006 Elsevier SAS. All rights reserved.
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页码：1406 / 1418
页数：13
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