Synthesis of 2-amino-4-(2-ethoxybenzo[d][1,3]dioxol-5-yl)-4H-pyran-3-Carbonitrile Derivatives and Their Biological Evaluation

A new class of substituted 2-amino-4-(2-ethoxybenzo[d][1,3]dioxol-5-yl)-4H-pyran-3-carbonitrile derivatives catalyzed by Imidazole under mild reaction conditions has been developed. A variety of functionalized 2-amino-4-(2-ethoxybenzo[d][1,3]dioxol-5-yl)-4H-pyran-3-carbonitrile scaffolds were assembled in high yields by this catalytic protocol. The newly synthesized compounds have been characterized by IR, H-1 NMR, C-13 NMR, and mass spectral data. The compounds were then evaluated for antimicrobial activities.