Organ preserving strategies for rectal cancer treatment

被引：2

作者：

Vendrely, V. ^{[1
]}

Denost, Q. ^{[2
]}

Amestoy, F. ^{[1
]}

Celerier, B. ^{[2
]}

Smith, D. ^{[3
]}

Rullier, A. ^{[4
]}

Rullier, E. ^{[2
]}

机构：

[1] Hop Haut Leveque, Serv Radiotherapie, F-33604 Pessac, France

[2] Hop St Andre, Serv Chirurg Viscerale, F-33000 Bordeaux, France

[3] Hop St Andre, Serv Oncol Med, F-33000 Bordeaux, France

[4] Hop Pellegrin, Serv Anatomopathol, F-33000 Bordeaux, France

来源：

CANCER RADIOTHERAPIE | 2015年 / 19卷 / 6-7期

关键词：

Rectal cancer; Local excision; Organ preservation; Tumour response; Watch and wait; TOTAL MESORECTAL EXCISION; TRANSANAL ENDOSCOPIC MICROSURGERY; NEOADJUVANT CHEMORADIATION THERAPY; PHASE-III TRIAL; COMPLETE CLINICAL-RESPONSE; PREOPERATIVE RADIOTHERAPY; LOCAL EXCISION; NONOPERATIVE TREATMENT; RANDOMIZED-TRIAL; TUMOR RESPONSE;

D O I：

10.1016/j.canrad.2015.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

For rectal cancers, the current standard of care consists of chemoradiation followed by radical surgery with total mesorectal excision. Oncologic results are good, especially regarding local recurrence rates, but at the cost of high morbidity rates and poor anorectal, urinary and sexual function results. Since chemoradiation yields 15 to 25% pathological complete response, the role of radical surgery is questioned for patients presenting with good response after chemoradiation and two organ preservation strategies have been offered: watch and wait strategy and local excision strategy. The aim of this review is to give the results of organ preservation after chemoradiotherapy series and to highlight different questions regarding initial patient's selection, complete clinical response definition, risk of mesorectal nodal involvement, follow-up modalities as well as oncologic and functional results. (C) 2015 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：404 / 409

页数：6

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