Using systems approaches to address challenges for clinical implementation of pharmacogenomics

被引:14
作者
Karnes, Jason H. [1 ]
Van Driest, Sara [2 ,3 ]
Bowton, Erica A. [4 ]
Weeke, Peter E. [1 ]
Mosley, Jonathan D. [1 ]
Peterson, Josh F. [1 ,5 ]
Denny, Joshua C. [1 ,5 ]
Roden, Dan M. [1 ,6 ]
机构
[1] Vanderbilt Univ, Dept Med, Nashville, TN 37235 USA
[2] Vanderbilt Univ, Dept Pediat, Nashville, TN USA
[3] Monroe Carell Jr Childrens Hosp Vanderbilt, Nashville, TN USA
[4] Vanderbilt Univ, Off Personalized Med, Nashville, TN 37235 USA
[5] Vanderbilt Univ, Dept Biomed Informat, Nashville, TN 37235 USA
[6] Vanderbilt Univ, Dept Pharmacol, Nashville, TN USA
关键词
CELL-DERIVED CARDIOMYOCYTES; CONSORTIUM GUIDELINES; PERSONALIZED MEDICINE; ASSOCIATION; BIOLOGY; RESISTANCE; MANAGEMENT; PATHWAYS; GENOTYPE; PATTERNS;
D O I
10.1002/wsbm.1255
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Many genetic variants have been shown to affect drug response through changes in drug efficacy and likelihood of adverse effects. Much of pharmacogenomic science has focused on discovering and clinically implementing single gene variants with large effect sizes. Given the increasing complexities of drug responses and their variability, a systems approach may be enabling for discovery of new biology in this area. Further, systems approaches may be useful in addressing challenges in moving these data to clinical implementation, including creation of predictive models of drug response phenotypes, improved clinical decision-making through complex biological models, improving strategies for integrating genomics into clinical practice, and evaluating the impact of implementation programs on public health. WIREs Syst Biol Med 2014, 6:125-135. doi: 10.1002/wsbm.1255 For further resources related to this article, please visit the . Conflict of interest: The authors have declared no conflicts of interest for this article.
引用
收藏
页码:125 / 135
页数:11
相关论文
共 54 条
[1]   Primary Care Guidelines for the Management of Persons Infected with Human Immunodeficiency Virus: 2009 Update by the HIV Medicine Association of the Infectious Diseases Society of America [J].
Aberg, Judith A. ;
Kaplan, Jonathan E. ;
Libman, Howard ;
Emmanuel, Patricia ;
Anderson, Jean R. ;
Stone, Valerie E. ;
Oleske, James M. ;
Currier, Judith S. ;
Gallant, Joel E. .
CLINICAL INFECTIOUS DISEASES, 2009, 49 (05) :651-681
[2]   Functional mapping of drug response with pharmacodynamic-pharmacokinetic principles [J].
Ahn, Kwangmi ;
Luo, Jiangtao ;
Berg, Arthur ;
Keefe, David ;
Wu, Rongling .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2010, 31 (07) :306-311
[3]   2012 ACCF/AHA Focused Update Incorporated Into the ACCF/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines [J].
Anderson, Jeffrey L. ;
Adams, Cynthia D. ;
Antman, Elliott M. ;
Bridges, Charles R. ;
Califf, Robert M. ;
Casey, Donald E., Jr. ;
Chavey, William E., II ;
Fesmire, Francis M. ;
Hochman, Judith S. ;
Levin, Thomas N. ;
Lincoff, A. Michael ;
Peterson, Eric D. ;
Theroux, Pierre ;
Wenger, Nanette K. ;
Wright, R. Scott ;
Jneid, Hani ;
Anderson, Jeffrey L. ;
Wright, R. Scott ;
Adams, Cynthia D. ;
Bridges, Charles R. ;
Casey, Donald E., Jr. ;
Ettinger, Steven M. ;
Fesmire, Francis M. ;
Ganiats, Theodore G. ;
Lincoff, A. Michael ;
Peterson, Eric D. ;
Philippides, George J. ;
Theroux, Pierre ;
Wenger, Nanette K. ;
Zidar, James Patrick .
CIRCULATION, 2013, 127 (23) :E663-E828
[4]   Evaluation in health informatics: social network analysis [J].
Anderson, JG .
COMPUTERS IN BIOLOGY AND MEDICINE, 2002, 32 (03) :179-193
[5]   Guidelines for prescribing azathioprine in dermatology [J].
Anstey, AV ;
Wakelin, S ;
Reynolds, NJ .
BRITISH JOURNAL OF DERMATOLOGY, 2004, 151 (06) :1123-1132
[6]   Analysis of PPARα-dependent and PPARα-independent transcript regulation following fenofibrate treatment of human endothelial cells [J].
Araki, Hiromitsu ;
Tamada, Yoshinori ;
Imoto, Seiya ;
Dunmore, Ben ;
Sanders, Deborah ;
Humphrey, Sally ;
Nagasaki, Masao ;
Doi, Atsushi ;
Nakanishi, Yukiko ;
Yasuda, Kaori ;
Tomiyasu, Yuki ;
Tashiro, Kousuke ;
Print, Cristin ;
Charnock-Jones, D. Stephen ;
Kuhara, Satoru ;
Miyano, Satoru .
ANGIOGENESIS, 2009, 12 (03) :221-229
[7]   Multi-professional patterns and methods of communication during patient handoffs [J].
Benham-Hutchins, Marge M. ;
Effken, Judith A. .
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS, 2010, 79 (04) :252-267
[8]   Social Network Analysis in Healthcare Settings: A Systematic Scoping Review [J].
Chambers, Duncan ;
Wilson, Paul ;
Thompson, Carl ;
Harden, Melissa .
PLOS ONE, 2012, 7 (08)
[9]   Pharmaco-metabonomic phenotyping and personalized drug treatment [J].
Clayton, TA ;
Lindon, JC ;
Cloarec, O ;
Antti, H ;
Charuel, C ;
Hanton, G ;
Provost, JP ;
Le Net, JL ;
Baker, D ;
Walley, RJ ;
Everett, JR ;
Nicholson, JK .
NATURE, 2006, 440 (7087) :1073-1077
[10]   Implications of the Human Genome Project for medical science [J].
Collins, FS ;
McKusick, VA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (05) :540-544