Biological activity of secondary metabolites from Peltostigma guatemalense

被引：14

作者：

Cuca Suarez, Luis Enrique ^{[2
]}

Pattarroyo, Manuel Elkin ^{[2
]}

Lozano, Jose Manuel ^{[3
]}

Delle Monache, Franco ^{[1
]}

机构：

[1] Univ Rome, Dipartimento Chim & Tecnol Sostanze Biologicament, Rome, Italy

[2] Univ Nacl Colombia, Dept Quim, Bogota, Colombia

[3] Fdn Inst Inmunol FIDIC, Bogota, Colombia

来源：

NATURAL PRODUCT RESEARCH | 2009年 / 23卷 / 04期

关键词：

Peltostigma guatemalense; furoquinolines; gardenin B; scopoletin; antibacterial; antimalarial; ALKALOIDS;

D O I：

10.1080/14786410802228439

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Leaves and wood of Peltostigma guatemalense, a novel species of the family Rutaceae, yielded a total of 14 secondary metabolites, i.e. methyl p-hydroxy benzoate, phenylacetic acid, -sitosterol, lupeol, syringaresinol, scopoletin, gardenin B (1), and seven alkaloids: -fagarine (2), skimmianine (3), kokusaginine (4), 7-O-isopentenyl--fagarine (5), anhydro-evoxine (6), evoxine (7) and 4-methoxy-1-methyl-quinolin-2-one (8). The compounds have been identified by spectroscopic methods. Antibacterial and antimalarial in vitro activity of the isolated compounds were also determined. Methyl p-hydroxy benzoate and quinolone (8) were the most effective on Plasmodium falciparium strains.

引用

页码：370 / 374

页数：5

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