Sequential Cu(I)/Pd(0)-Catalyzed Multicomponent Coupling and Annulation Protocol for the Synthesis of Indenoisoquinolines

被引：11
作者：
Jayanth, Thiruvellore Thatai
Zhang, Lei
Johnson, Thomas S.
Malinakova, Helena C. [1 ]
机构：
[1] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 04期
基金：
美国国家卫生研究院;
关键词：
TOPOISOMERASE-I INHIBITORS; BIOLOGICAL EVALUATION; ACID-CHLORIDES; ISOMERIZATION; HETEROCYCLES; DERIVATIVES; INSERTION; DESIGN; IMINES; RING;
D O I：
10.1021/ol802755z
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.
引用
收藏
页码：815 / 818
页数：4
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