Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T

被引:51
作者
Yankeelov, Thomas E.
DeBusk, Laura M.
Billheimer, D. Dean
Luci, Jeffrey J.
Lin, P. Charles
Price, Ronald R.
Gore, John C.
机构
[1] Vanderbilt Univ, Med Ctr, Inst Imaging Sci, Nashville, TN 37232 USA
[2] Vanderbilt Univ, Dept Radiol & Radiol Sci, Nashville, TN USA
[3] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA
[4] Vanderbilt Univ, Dept Phys & Astron, Nashville, TN 37235 USA
[5] Vanderbilt Univ, Dept Canc Biol, Nashville, TN USA
[6] Vanderbilt Univ, Dept Biostat, Nashville, TN USA
[7] Vanderbilt Univ, Dept Radiat Oncol, Nashville, TN USA
关键词
DCE-MRI; tumor pharmacokinetics; reference region; repeatability; kinetic modelling;
D O I
10.1002/jmri.20729
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose: To test the repeatability of a reference region (RR.) model for the analysis of dynamic contrast-enhanced MRI (DCE-MRI) in a mouse model of cancer at high field. Materials and Methods: Seven mice were injected with 106 4T1 mammary carcinoma cells and imaged eight to 10 days later on a Varian 7.0T scanner. Two DCE-MRI studies were performed for each mouse (separated by 2.5 hours). The RR model was,used to, analyze the data, and, returned estimates on the perfusion-permeability index (K-trans) for the RR and the tissue of interest (TOI), as well as the extravascular extracellular volume fraction (v(e)) for the TOI. Results: Whent he first injection,Was compared with the second injectiori, all baxameters. tested were highly correlated (r(2) = 0.90, 0.62, 0.82 for the RR K-trans, TOT K-trans, and`TOI v(e), respectively, with P < 0.001 for all). To observe a statistically significant change (at the 5%-level) in a treatment study with 1 seven animals in each group log(10) chapges,of 0.084 and 0.077 in the tumor K-trans and v(e), respectively, are required Conclusion: If a reliable arterial input function (AIF) is unavailable, the RR model is a reasonable alternative to measuring MRI contrast-agent (CA) kinetics in mouse models of cancer at high field.
引用
收藏
页码:1140 / 1147
页数:8
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