Benefits of Surgical Over Medical Treatment for Unilateral Primary Aldosteronism

被引：13

作者：

Ahmed, Sumaiya ^{[1
]}

Hundemer, Gregory L. ^{[2
,3
]}

机构：

[1] Univ Ottawa, Ottawa Hosp, Dept Med, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Med, Div Nephrol, Ottawa, ON, Canada

[3] Univ Ottawa, Ottawa Hosp Res Inst, Ottawa, ON, Canada

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

基金：

加拿大健康研究院;

关键词：

primary aldosteronism; hyperaldosteronism; Conn syndrome; surgery; adrenalectomy; unilateral; QUALITY-OF-LIFE; TREATED PRIMARY ALDOSTERONISM; CLINICAL-OUTCOMES; LAPAROSCOPIC ADRENALECTOMY; MINERALOCORTICOID RECEPTOR; PRIMARY HYPERALDOSTERONISM; ESSENTIAL-HYPERTENSION; CARDIOVASCULAR EVENTS; METABOLIC SYNDROME; DIABETES-MELLITUS;

D O I：

10.3389/fendo.2022.861581

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary aldosteronism is the most common and modifiable form of secondary hypertension. Left untreated, primary aldosteronism leads high rates of cardiovascular, metabolic, and kidney disease. Therefore, early diagnosis and targeted therapy are crucial to improve long-term patient outcomes. In the case of unilateral primary aldosteronism, surgical adrenalectomy is the guideline-recommended treatment of choice as compared to alternative medical therapies such as mineralocorticoid receptor antagonist medications. Surgical adrenalectomy is not only highly successful in reversing the biochemical abnormalities inherent to primary aldosteronism, but also in mitigating the long-term risks associated with this disease. Indeed, as opposed to medical treatment alone, surgical adrenalectomy offers the potential for disease cure. Within this review article, we review the existing evidence highlighting the benefits of surgical over medical treatment for unilateral primary aldosteronism.

引用

页数：8

共 78 条

[1] Primary Aldosteronism Decreases Insulin Secretion and Increases Insulin Clearance in Humans [J].

Adler, Gail K. ;

Murray, Gillian R. ;

Turcu, Adina F. ;

Nian, Hui ;

Yu, Chang ;

Solorzano, Carmen C. ;

Manning, Robert ;

Peng, Dungeng ;

Luther, James M. .

HYPERTENSION, 2020, 75 (05) :1251-1259

[2] Quality of Life in Patients with Bilateral Primary Aldosteronism before and during Treatment with Spironolactone and/or Amiloride, Including a Comparison with Our Previously Published Results in Those with Unilateral Disease Treated Surgically [J].

Ahmed, Ashraf H. ;

Gordon, Richard D. ;

Sukor, Norlela ;

Pimenta, Eduardo ;

Stowasser, Michael .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (09) :2904-2911

[3] Sex Difference in the Association Between Subtype Distribution and Age at Diagnosis in Patients With Primary Aldosteronism [J].

Akasaka, Hiroshi ;

Yamamoto, Koichi ;

Rakugi, Hiromi ;

Nagasawa, Motonori ;

Nakamaru, Ryo ;

Ichijo, Takamasa ;

Takeda, Yoshiyu ;

Kurihara, Isao ;

Katabami, Takuyuki ;

Tsuiki, Mika ;

Wada, Norio ;

Ogawa, Yoshihiro ;

Kawashima, Junji ;

Sone, Masakatsu ;

Kamemura, Kohei ;

Yoshimoto, Takanobu ;

Matsuda, Yuichi ;

Fujita, Megumi ;

Kobayashi, Hiroki ;

Watanabe, Minemori ;

Tamura, Kouichi ;

Okamura, Shintaro ;

Miyauchi, Shozo ;

Izawa, Shoichiro ;

Chiba, Yoshiro ;

Tanabe, Akiyo ;

Naruse, Mitsuhide .

HYPERTENSION, 2019, 74 (02) :368-374

[4] High Prevalence of Diabetes in Patients With Primary Aldosteronism (PA) Associated With Subclinical Hypercortisolism and Prediabetes More Prevalent in Bilateral Than Unilateral PA: A Large, Multicenter Cohort Study in Japan [J].

Akehi, Yuko ;

Yanase, Toshihiko ;

Motonaga, Ryoko ;

Umakoshi, Hironobu ;

Tsuiki, Mika ;

Takeda, Yoshiyu ;

Yoneda, Takashi ;

Kurihara, Isao ;

Itoh, Hiroshi ;

Katabami, Takuyuki ;

Ichijo, Takamasa ;

Wada, Norio ;

Shibayama, Yui ;

Yoshimoto, Takanobu ;

Ashida, Kenji ;

Ogawa, Yoshihiro ;

Kawashima, Junji ;

Sone, Masakatsu ;

Inagaki, Nobuya ;

Takahashi, Katsutoshi ;

Fujita, Megumi ;

Watanabe, Minemori ;

Matsuda, Yuichi ;

Kobayashi, Hiroki ;

Shibata, Hirotaka ;

Kamemura, Kohei ;

Otsuki, Michio ;

Fujii, Yuichi ;

Yamamoto, Koichi ;

Ogo, Atsushi ;

Okamura, Shintaro ;

Miyauchi, Shozo ;

Fukuoka, Tomikazu ;

Izawa, Shoichiro ;

Hashimoto, Shigeatsu ;

Yamada, Masanobu ;

Yoshikawa, Yuichiro ;

Kai, Tatsuya ;

Suzuki, Tomoko ;

Kawamura, Takashi ;

Naruse, Mitsuhide .

DIABETES CARE, 2019, 42 (05) :938-945

[5] Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism [J].

Arlt, Wiebke ;

Lang, Katharina ;

Sitch, Alice J. ;

Dietz, Anna S. ;

Rhayem, Yara ;

Bancos, Irina ;

Feuchtinger, Annette ;

Chortis, Vasileios ;

Gilligan, Lorna C. ;

Ludwig, Philippe ;

Riester, Anna ;

Asbach, Evelyn ;

Hughes, Beverly A. ;

O'Neil, Donna M. ;

Bidlingmaier, Martin ;

Tomlinson, Jeremy W. ;

Hassan-Smith, Zaki K. ;

Rees, D. Aled ;

Adolf, Christian ;

Hahner, Stefanie ;

Quinkler, Marcus ;

Dekkers, Tanja ;

Deinum, Jaap ;

Biehl, Michael ;

Keevil, Brian G. ;

Shackleton, Cedric H. L. ;

Deeks, Jonathan J. ;

Walch, Axel K. ;

Beuschlein, Felix ;

Reincke, Martin .

JCI INSIGHT, 2017, 2 (08)

[6] Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors [J].

Briet, Marie ;

Barhoumi, Tlili ;

Mian, Muhammad Oneeb Rehman ;

Coelho, Suellen C. ;

Ouerd, Sofiane ;

Rautureau, Yohann ;

Coffman, Thomas M. ;

Paradis, Pierre ;

Schiffrin, Ernesto L. .

HYPERTENSION, 2016, 67 (05) :897-905

[7] The Unrecognized Prevalence of Primary Aldosteronism A Cross-sectional Study [J].

Brown, Jenifer M. ;

Siddiqui, Mohammed ;

Calhoun, David A. ;

Carey, Robert M. ;

Hopkins, Paul N. ;

Williams, Gordon H. ;

Vaidya, Anand .

ANNALS OF INTERNAL MEDICINE, 2020, 173 (01) :10-+

[8] Cardiovascular outcomes in patients with primary aldosteronism after treatment [J].

Catena, Cristiana ;

Colussi, GianLuca ;

Nadalini, Elisa ;

Chiuch, Alessandra ;

Baroselli, Sara ;

Lapenna, Roberta ;

Sechi, Leonardo A. .

ARCHIVES OF INTERNAL MEDICINE, 2008, 168 (01) :80-85

[9]

Celen O, 1996, ARCH SURG-CHICAGO, V131, P646

[10] Elevated prevalence of abnormal glucose metabolism in patients with primary aldosteronism: a meta-analysis [J].

Chen, W. ;

Li, F. ;

He, C. ;

Zhu, Y. ;

Tan, W. .

IRISH JOURNAL OF MEDICAL SCIENCE, 2014, 183 (02) :283-291

← 1 2 3 4 5 6 7 8 →