Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?

被引:10
作者
Low, Michael [1 ,2 ,3 ]
Infantino, Simona [1 ,3 ]
Grigoriadis, George [2 ,4 ,5 ,6 ,7 ]
Tarlinton, David [1 ,2 ]
机构
[1] Univ Melbourne, Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3052, Australia
[2] Monash Hosp, Monash Hlth, Dept Haematol, Clayton, Vic, Australia
[3] Univ Melbourne, Dept Med Biol, Parkville, Vic 3052, Australia
[4] Monash Univ, Monash Hlth, Sch Clin Sci, Clayton, Vic, Australia
[5] Hudson Inst Med Res, Ctr Canc Res, Clayton, Vic, Australia
[6] Alfred, Malignant Haematol & Stem Cell Transplantat Serv, Melbourne, Vic, Australia
[7] Alfred, Alfred Pathol Serv, Melbourne, Vic, Australia
基金
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
antibody-secreting cells; plasma cells; therapeutics; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GERMINAL-CENTER FORMATION; PROTEASOME INHIBITOR BORTEZOMIB; UNDETERMINED SIGNIFICANCE MGUS; SMOLDERING MULTIPLE-MYELOMA; UNFOLDED PROTEIN RESPONSE; MONOCLONAL GAMMOPATHY; BONE-MARROW; B-CELLS; DOUBLE-BLIND;
D O I
10.1111/imr.12388
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Antibody-secreting cells (ASCs) are critical for a functional and effective adaptive immune system. In a number of illnesses, however, these same cells contribute to the underlying disease state leading to significant morbidity and mortality. While therapeutic targeting of antibody-secreting cells has progressed significantly over the last two decades, many of these conditions remain major health problems. In this review, we will discuss current and potential therapeutic targeting of ASCs in the context of the known biology of these cells.
引用
收藏
页码:78 / 94
页数:17
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