Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer

被引：321

作者：

Ramos, Rodrigo Nalio ^{[1
,2
,14
,15
]}

Missolo-Koussou, Yoann ^{[1
,2
]}

Gerber-Ferder, Yohan ^{[1
,2
]}

Bromley, Christian P. ^{[3
]}

Bugatti, Mattia ^{[4
]}

Nunez, Nicolas Gonzalo ^{[1
,2
,16
]}

Boari, Jimena Tosello ^{[1
,2
]}

Richer, Wilfrid ^{[1
,2
]}

Menger, Laurie ^{[1
]}

Denizeau, Jordan ^{[1
,2
]}

Sedlik, Christine ^{[1
,2
]}

Caudana, Pamela ^{[1
,2
]}

Kotsias, Fiorella ^{[1
,2
]}

Niborski, Leticia L. ^{[1
,2
]}

Viel, Sophie ^{[1
,2
]}

Bohec, Mylene ^{[6
]}

Lameiras, Sonia ^{[6
]}

Baulande, Sylvain ^{[6
]}

Lesage, Laetitia ^{[7
]}

Nicolas, Andre ^{[7
]}

Meseure, Didier ^{[7
]}

Vincent-Salomon, Anne ^{[7
]}

Reyal, Fabien ^{[8
]}

Dutertre, Charles-Antoine ^{[9
]}

Ginhoux, Florent ^{[9
,10
]}

Vimeux, Lene ^{[11
]}

Donnadieu, Emmanuel ^{[11
]}

Buttard, Benedicte ^{[12
]}

Galon, Jerome ^{[12
]}

Zelenay, Santiago ^{[3
]}

Vermi, William ^{[1
,5
]}

Guermonprez, Pierre ^{[13
]}

Piaggio, Eliane ^{[1
,2
]}

Helft, Julie ^{[1
,2
]}

机构：

[1] PSL Univ, Inst Curie Res Ctr, U932, INSERM, F-75005 Paris, France

[2] PSL Univ, SiRIC, Translat Immunotherapy Team, F-75005 Paris, France

[3] Univ Manchester, Canc Res UK Manchester Inst, Canc Inflammat & Immun Grp, Alderley Pk, Manchester, Lancs, England

[4] Univ Brescia, Dept Pathol, I-25123 Brescia, Italy

[5] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO 63110 USA

[6] PSL Univ, Inst Curie Res Ctr, Inst Curie Genom Excellence Platform, F-75005 Paris, France

[7] PSL Univ, Inst Curie Hosp, Dept Pathol, F-75005 Paris, France

[8] PSL Univ, Inst Curie Hosp, Dept Surg, F-75005 Paris, France

[9] Univ Paris Saclay, Inst Gustave Roussy, INSERM, U1015, Villejuif, France

[10] Agcy Sci Technol & Res, Singapore Immunol Network, Singapore 138648, Singapore

[11] Univ Paris, Inst Cochin, INSERM, CNRS,UMR 8104,U1016, F-75014 Paris, France

[12] Univ Paris, Sorbonne Univ, Ctr Rech Cordeliers, Lab Integrat Canc Immunol,INSERM, Paris, France

[13] Univ Paris, Ctr Inflammat Res, INSERM1149, CNRS,ERL8252, Paris, France

[14] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP,Dept Hematol & Cell Therapy, Lab Med Invest Pathogenesis & Directed Therapy On, Sao Paulo, Brazil

[15] Inst DOr Ensino & Pesquisa, Sao Paulo, Brazil

[16] Univ Zurich, Inst Expt Immunol, Zurich, Switzerland

来源：

CELL | 2022年 / 185卷 / 07期

基金：

英国生物技术与生命科学研究理事会;

关键词：

TUMOR-ASSOCIATED MACROPHAGES; GENE-EXPRESSION; DENDRITIC CELLS; R/BIOCONDUCTOR PACKAGE; INFLAMMATORY MONOCYTES; LYMPH-NODES; POLARIZATION; CYTOMETRY; ORIGIN; METASTASIS;

D O I：

10.1016/j.cell.2022.02.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophage infiltration is a hallmark of solid cancers, and overall macrophage infiltration correlates with lower patient survival and resistance to therapy. Tumor-associated macrophages, however, are phenotypically and functionally heterogeneous. Specific subsets of tumor-associated macrophage might be endowed with distinct roles on cancer progression and antitumor immunity. Here, we identify a discrete population of FOLR2(+) tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors. FOLR2(+) macrophages localize in perivascular areas in the tumor stroma, where they interact with CD8(+) T cells. FOLR2(+) macrophages efficiently prime effector CD8(+) T cells ex vivo. The density of FOLR2(+) macrophages in tumors positively correlates with better patient survival. This study highlights specific roles for tumor-associated macrophage subsets and paves the way for subset-targeted therapeutic interventions in macrophages-based cancer therapies.

引用

页码：1189 / +

页数：45

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