Amyloid fibril inhibition, acceleration, or fragmentation; Are nano-based approaches advance in the right direction?

被引：10

作者：

Hajipour, Mohammad Javad ^{[1
,2
]}

Mohammad-Beigi, Hossein ^{[3
]}

Nabipour, Iraj ^{[2
]}

Mahmoudi, Negar ^{[4
]}

Azhdarzadeh, Morteza ^{[5
,6
]}

Derakhshankhah, Hossein ^{[7
]}

El Dawud, Dina ^{[8
]}

Mohammadinejad, Reza ^{[9
]}

Otzen, Daniel E. ^{[3
]}

机构：

[1] Michigan State Univ, Precis Hlth Program, E Lansing, MI 48824 USA

[2] Bushehr Univ Med Sci, Persian Gulf Marine Biotechnol Res Ctr, Persian Gulf Biomed Sci Res Inst, Bushehr 75147, Iran

[3] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark

[4] Univ Tehran Med Sci, Noncommunicable Dis Res Ctr, Endocrinol & Metab Populat Sci Inst, Tehran, Iran

[5] Univ Tehran Med Sci, Fac Pharm, Dept Nanotechnol, Tehran, Iran

[6] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran

[7] Kermanshah Univ Med Sci, Pharmaceut Sci Res Ctr, Kermanshah, Iran

[8] Univ Jordan, Dept Pharm, Amman, Jordan

[9] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, Kerman, Iran

来源：

NANO TODAY | 2020年 / 35卷

关键词：

Alzheimer's disease; Fibrillation; A beta; Nanotechnology; Nanoparticles; BETA PROTEIN FIBRILLATION; ALZHEIMERS-DISEASE; A-BETA; TAU AGGREGATION; OLIGOMER LEVELS; DRUG DISCOVERY; NANOPARTICLES; FIBRILLIZATION; DEFICITS; PLAQUES;

D O I：

10.1016/j.nantod.2020.100983

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanotechnology-based approaches have shown promising potential to overcome the challenges associated with current therapeutic/diagnostic approaches and offer exciting solutions to improve the quality of life of Alzheimer's Disease (AD) patients. Unfortunately, thus far they have failed in clinical translation. These disappointing results question whether nanotechnology-based therapeutic strategies are heading in the right direction. Here, we re-consider the problems and current therapeutic approaches from new angles and suggest what might have been overlooked in advanced AD therapy. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：5

共 55 条

[1] β-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system [J].