Local therapy combined with chemotherapy versus chemotherapy for postoperative oligometastatic non-small-cell lung cancer

被引：8
作者：
Shang, Shuheng [1 ,2 ]
Wang, Linlin [2 ]
Su, Yi [3 ]
Li, Butuo [2 ,4 ]
Guo, Meiying [1 ,2 ]
Zhu, Zhaofeng [5 ]
Sun, Xindong [2 ]
Yu, Jinming [2 ]
机构：
[1] Shandong Univ, Sch Med, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China
[2] Shandong Univ, Shandong Acad Med Sci, Dept Radiat Oncol, Shandong Canc Hosp, Jinan 250117, Shandong, Peoples R China
[3] Qingdao Univ Inst, Affiliated Yantai Yuhuangding Hosp, Dept Radiotherapy, Yantai 264009, Peoples R China
[4] Tianjin Med Univ, Dept Radiat Oncol, Tianjin 300070, Peoples R China
[5] Taian Cent Hosp, Dept Radiotherapy, Tai An 271000, Shandong, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 14期
基金：
中国国家自然科学基金;
关键词：
chemotherapy; local ablative therapy; non-small-cell lung cancer; oligometastases; postoperation; STEREOTACTIC BODY RADIOTHERAPY; LONG-TERM SURVIVAL; RECURRENCE; OUTCOMES; TUMOR;
D O I：
10.2217/fon-2018-0923
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To compare the efficacy and toxicity of local therapy plus chemotherapy versus chemotherapy in non-small-cell lung cancer (NSCLC) patients with oligometastases after surgery. Patients & methods: A total of 152 patients with oligometastases after surgery were enrolled. Data of patient survival, treatment response and toxicities were compared between the groups receiving local ablative therapy plus chemotherapy and chemotherapy alone. Results: Compared with chemotherapy, the combination treatment conferred better progression-free survival, objective response rate and disease control rate (10 vs 7 months; 66.7 vs 31.9%; 94.3 vs 80.9%, respectively), but with more grade >= 3 adverse events. Besides, the overall survival was not significantly different (19 vs 20 months). Conclusion: The addition of local therapy to chemotherapy improved progression-free survival, objective response rate and disease control rate, but not overall survival in postoperative oligometastatic non-small-cell lung cancer.
引用
收藏
页码：1593 / 1603
页数：11
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