Influenza virus surveillance in Argentina during the 2012 season: antigenic characterization, genetic analysis and antiviral susceptibility

被引：2

作者：

Benedetti, E. ^{[1
]}

Daniels, R. S. ^{[2
]}

Pontoriero, A. ^{[1
]}

Russo, M. ^{[1
]}

Avaro, M. ^{[1
]}

Czech, A. ^{[1
]}

Campos, A. ^{[1
]}

Periolo, N. ^{[1
]}

Gregory, V. ^{[2
]}

McCauley, J. W. ^{[2
]}

Baumeister, E. G. ^{[1
]}

机构：

[1] ANLIS Carlos G Malbran, Inst Nacl Enfermedades Infecciosas, Dept Virol, Natl Influenza Ctr PAHO WHO,Serv Virosis Resp, Av Velez Sarsfield 563,C1282AFF, Buenos Aires, DF, Argentina

[2] Francis Crick Inst, Mill Hill Lab, London, England

来源：

EPIDEMIOLOGY AND INFECTION | 2016年 / 144卷 / 04期

关键词：

Influenza; influenza vaccines; resistance to drugs; respiratory infections; surveillance; NEURAMINIDASE INHIBITORS; RESISTANCE; CHILDREN; A(H3N2);

D O I：

10.1017/S0950268815001806

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The activity and circulation of influenza viruses in Argentina was studied during 2012 as part of the Argentinean Surveillance for Influenza and other Respiratory Viruses, in the context of Global Influenza Surveillance. The antigenicity and molecular characteristics of haemagglutinins (HA) of circulating influenza A and B viruses were analysed to assess the emergence of virus variants. Susceptibility to oseltamivir and zanamivir was evaluated by enzymatic assay and results were backed-up by sequencing of the neuraminidase (NA) genes. During the 2012 season, influenza virus circulation in Argentina was detected from weeks 24 to 51. The HA sequences of the studied A(H1N1)pdm09 subtype viruses segregated in a different genetic group compared to those identified during the 2009 pandemic, although they were still closely related antigenically to the vaccine virus A/California/07/2009. The HA sequences of the A(H3N2) viruses analysed fell into the A/Victoria/208/2009 clade, genetic group 3C. A mixed circulation of virus variants belonging to B/Victoria and B/Yamagata lineages was detected, with B/Victoria being dominant. All viruses tested were sensitive to oseltamivir and zanamivir except one. This isolate, an A(H1N1)pdm09 virus possessing the substitution NA-N295S, showed highly reduced inhibition by oseltamivir and reduced inhibition by zanamivir. Virological and epidemiological surveillance remains critical for detection of evolving influenza viruses.

引用

页码：751 / 767

页数：17

共 35 条

[1]

Abed Y, 2006, ANTIVIR THER, V11, P971

[2]

AMH, 2012, AMH B INT VIG

[3]

[Anonymous], 2012, Wkly Epidemiol Rec, V87, P422

[4]

[Anonymous], 2012, Wkly Epidemiol Rec, V87, P369

[5]

[Anonymous], 2008, Wkly Epidemiol Rec, V83, P81

[6]

[Anonymous], 2011, Manual for the laboratory diagnosis and virological surveillance of influenza, P43

[7]

[Anonymous], 2012, HUM VACC IMMUNOTHER, DOI DOI 10.4161/HV.18569

[8] Epidemiological, antigenic and genetic characteristics of seasonal influenza A(H1N1), A(H3N2) and B influenza viruses: Basis for the WHO recommendation on the composition of influenza vaccines for use in the 2009-2010 Northern Hemisphere season [J].

Barr, Ian G. ;

McCauley, John ;

Cox, Nancy ;

Daniels, Rod ;

Engelhardt, Othmar G. ;

Fukuda, Keiji ;

Grohmann, Gary ;

Hay, Alan ;

Kelso, Anne ;

Klimov, Alexander ;

Odagiri, Takato ;

Smith, Derek ;

Russell, Colin ;

Tashiro, Masato ;

Webby, Richard ;

Wood, John ;

Ye, Zhiping ;

Zhang, Wenqing .

VACCINE, 2010, 28 (05) :1156-1167

[9]

Ciblak MA, 2012, MIKROBIYOL BUL, V46, P575

[10] Structural basis for oseltamivir resistance of influenza viruses [J].

Collins, P. J. ;

Haire, L. F. ;

Lin, Y. P. ;

Liu, J. ;

Russell, R. J. ;

Walker, P. A. ;

Martin, S. R. ;

Daniels, R. S. ;

Gregory, V. ;

Skehel, J. J. ;

Gamblin, S. J. ;

Hay, A. J. .

VACCINE, 2009, 27 (45) :6317-6323

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