Electron Relay Race in Peptides

被引：83

作者：

Giese, Bernd ^{[1
]}

Wang, Min ^{[1
]}

Gao, Jian ^{[1
]}

Stoltz, Moritz ^{[1
]}

Mueller, Pavel ^{[1
]}

Graber, Michael ^{[1
]}

机构：

[1] Univ Basel, CH-4056 Basel, Switzerland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 10期

基金：

瑞士国家科学基金会;

关键词：

TRYPTOPHAN; OXIDATION;

D O I：

10.1021/jo900375f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A peptide assay was developed that allows the measurement of electron-transfer (ET) efficiencies in peptides. It turns out that two-step ET processes are faster than single-step reactions. This requires relay amino acids with appropriate redox potentials. Not only aromatic but also sulfur-containing aliphatic amino acids can act as stepping stones for the charge. With tryptophan, histidine, and cysteine the reaction is a more complex proton-coupled ET.

引用

收藏

页码：3621 / 3625

页数：5

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