Prenatal exposure to perfluoroalkyl substances and cord plasma lipid concentrations

被引：23

作者：

Tian, Youping ^{[1
,2
]}

Miao, Maohua ^{[2
]}

Ji, Honglei ^{[2
]}

Zhang, Xiaotian ^{[3
]}

Chen, Aimin ^{[4
]}

Wang, Ziliang ^{[2
]}

Yuan, Wei ^{[2
]}

Liang, Hong ^{[2
]}

机构：

[1] Fudan Univ, Natl Management Off Neonatal Screening Project CH, Childrens Hosp, 399 Wanyuan Rd, Shanghai 201102, Peoples R China

[2] Fudan Univ, NHC Key Lab Reprod Regulat, Shanghai Inst Planned Parenthood Res, 779 Old Hu Min Rd, Shanghai 200237, Peoples R China

[3] Hubei Prov Acad Prevent Med, Hubei Prov Ctr Dis Control & Prevent, Inst Hlth Inspect & Detect, Natl Reference Lab Dioxin, 6 Zhuo Daoquan North Rd, Wuhan 430079, Peoples R China

[4] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, 423 Guardian Dr, Philadelphia, PA 19104 USA

来源：

ENVIRONMENTAL POLLUTION | 2021年 / 268卷

关键词：

Perfluoroalkyl substances; Prenatal exposure; Lipids; Cord plasma; Shanghai-Minhang Birth Cohort Study; PREGNANT-WOMEN; PERFLUOROOCTANOIC ACID; TEMPORAL TRENDS; SERUM-LIPIDS; BLOOD; MOUSE; RISK; LIFE;

D O I：

10.1016/j.envpol.2020.115426

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The effect of prenatal exposure to perfluoroalkyl substances (PFAS) on lipid concentrations in newborns is unknown. Using data from the Shanghai-Minhang Birth Cohort Study, we prospectively assessed the health effects of prenatal exposure to individual and multiple PFAS on cord lipid concentrations. Maternal plasma samples collected at 12-16 weeks of gestation were analyzed for eleven PFAS, and cord blood samples were analyzed for lipids: total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). We used multiple linear regression models to evaluate the associations of each individual PFAS with each lipid parameter, and used Bayesian Kernel Machine Regression (BKMR) models to assess the overall and single-exposure effects of eight PFAS with the detection rate above 80% on cord lipid concentrations. In multiple linear regression models, for each unit increase in In-transformed maternal concentrations of perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), and perfluorotridecanoic acid (PFTrDA), In-transformed TC concentration decreased by 0.15 mg/dL (95% confidence interval (CI): -0.25, -0.05), 0.12 mg/dL (95% CI: -0.19, -0.05), 0.12 mg/dL (95% CI: -0.19, -0.05), and 0.05 mg/dL (95% CI: -0.09, -0.01), respectively, and In-transformed HDL-C concentration decreased by 0.17 mg/dL (95% CI: -0.29, -0.05), 0.12 mg/dL (95% CI: -0.20, -0.03), 0.12 mg/dL (95% CI: -0.20, -0.03), and 0.06 mg/dL (95% CI: -0.11, -0.00), respectively. Statistically significant inverse associations were also observed between In-transformed concentrations of PFDA, PFUdA, or PFTrDA and In-transformed cord concentrations of TG and LDL-C. In BKMR models, the mixture of eight PFAS showed suggestively inverse association with all In-transformed lipid concentrations, such that In-transformed TC concentration of exposure to the 75th percentile of the mixture was 0.11 units (95% credible interval, -0.21, -0.01) lower than the 25th percentile exposure. Our findings indicated that prenatal exposure to PFAS may disrupt lipid metabolism in newborns. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：9