Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study

被引:82
作者
Braun, Joseph M. [1 ]
Wright, Rosalind J. [2 ,3 ,4 ]
Just, Allan C. [5 ]
Power, Melinda C. [5 ,6 ]
Tamayo y Ortiz, Marcela [5 ]
Schnaas, Lourdes [7 ]
Hu, Howard [8 ]
Wright, Robert O. [2 ,3 ,4 ]
Maria Tellez-Rojo, Martha [9 ]
机构
[1] Brown Univ, Dept Epidemiol, Providence, RI 02912 USA
[2] Icahn Sch Med Mt Sinai, Dept Pediat, Pediat Kravis Childrens Hosp, New York, NY 10029 USA
[3] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA
[4] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA
[6] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[7] Natl Inst Publ Hlth, Ctr Evaluat Res & Surveys, Cuernavaca, Morelos, Mexico
[8] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[9] Natl Inst Perinatol, Div Res Publ Hlth, Mexico City, DF, Mexico
关键词
Lead; Cortisol; Epidemiology; Pregnancy; X-RAY-FLUORESCENCE; BONE LEAD; MATERNAL STRESS; EXPOSURE; BLOOD; RESORPTION; PREDICTOR; PLASMA;
D O I
10.1186/1476-069X-13-50
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Background: Lead (Pb) exposure during pregnancy may increase the risk of adverse maternal, infant, or childhood health outcomes by interfering with hypothalamic-pituitary-adrenal-axis function. We examined relationships between maternal blood or bone Pb concentrations and features of diurnal cortisol profiles in 936 pregnant women from Mexico City. Methods: From 2007-11 we recruited women from hospitals/clinics affiliated with the Mexican Social Security System. Pb was measured in blood (BPb) during the second trimester and in mothers' tibia and patella 1-month postpartum. We characterized maternal HPA-axis function using 10 timed salivary cortisol measurements collected over 2-days (mean: 19.7, range: 14-35 weeks gestation). We used linear mixed models to examine the relationship between Pb biomarkers and cortisol area under the curve (AUC), awakening response (CAR), and diurnal slope. Results: After adjustment for confounders, women in the highest quintile of BPb concentrations had a reduced CAR (Ratio: -13%; Confidence Interval [CI]: -24, 1, p-value for trend < 0.05) compared to women in the lowest quintile. Tibia/patella Pb concentrations were not associated with CAR, but diurnal cortisol slopes were suggestively flatter among women in the highest patella Pb quantile compared to women in the lowest quantile (Ratio: 14%; CI: -2, 33). BPb and bone Pb concentrations were not associated with cortisol AUC. Conclusions: Concurrent blood Pb levels were associated with cortisol awakening response in these pregnant women and this might explain adverse health outcomes associated with Pb. Further research is needed to confirm these results and determine if other environmental chemicals disrupt hypothalamic-pituitary-adrenal-axis function during pregnancy.
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页数:10
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