Two sides of the same coin: stem cells in cancer and regenerative medicine

被引：35

作者：

Ilmer, Matthias ^{[1
]}

Vykoukal, Jody ^{[1
]}

Boiles, Alejandro Recio ^{[1
]}

Coleman, Michael ^{[3
]}

Alt, Eckhard ^{[2
,4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Ctr Stem Cell & Dev Biol, Houston, TX 77030 USA

[3] InGeneron Inc, Houston, TX USA

[4] Tulane Univ, Hlth Sci Ctr, Dept Med, Appl Stem Cell Lab,Heart & Vasc Inst, New Orleans, LA 70118 USA

来源：

FASEB JOURNAL | 2014年 / 28卷 / 07期

关键词：

mesenchymal stromal cells; Warburg; epithelialmesenchymal transition; exosomes; EPITHELIAL-MESENCHYMAL TRANSITION; BONE-MARROW; STROMAL CELLS; TUMOR STROMA; TGF-BETA; ISCHEMIC CARDIOMYOPATHY; AEROBIC GLYCOLYSIS; PROGENITOR CELLS; TENASCIN-C; IN-VITRO;

D O I：

10.1096/fj.13-244640

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Multipotent stromal cells (MSCs) derived from bone marrow, adipose tissue, cord blood, and other origins have recently received much attention as potential therapeutic agents with beneficial immunomodulatory and regenerative properties. In their native tissue environment, however, such cells also appear to have essential functions in building and supporting tumor microenvironments, providing metastatic niches, and maintaining cancer hallmarks. Here, we consider the varied roles of these tissue-resident stroma-associated cells, synthesize recent and emerging discoveries, and discuss the role, potential, and clinical applications of MSCs in cancer and regenerative medicine.

引用

页码：2748 / 2761

页数：14

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