Determination of impurities and counterions of pharmaceuticals by capillary electromigration methods

被引：59

作者：

Stepanova, Sille ^{[1
]}

Kasicka, Vaclav ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Organ Chem & Biochem, CR-16610 Prague 6, Czech Republic

来源：

JOURNAL OF SEPARATION SCIENCE | 2014年 / 37卷 / 15期

关键词：

Capillary electrophoresis; Chiral impurities; Drug counterions; Drug impurities; Pharmaceutical analysis; CONTACTLESS CONDUCTIVITY DETECTION; MICELLAR ELECTROKINETIC CHROMATOGRAPHY; ENANTIOMERIC PURITY CONTROL; INDIRECT UV DETECTION; SUPERCRITICAL-FLUID CHROMATOGRAPHY; ELECTROPHORESIS-MASS SPECTROMETRY; DUAL CYCLODEXTRIN SYSTEM; INDICATING MEKC METHOD; CHIRAL SELECTOR; ZONE-ELECTROPHORESIS;

D O I：

10.1002/jssc.201400266

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The review presents a survey of recent applications of high-performance capillary electromigration methods-capillary zone electrophoresis, nonaqueous capillary electrophoresis, capillary isotachophoresis, micellar electrokinetic chromatography, microemulsion electrokinetic chromatography and capillary electrochromatography-for the determination of impurities of pharmaceuticals, including chiral impurities, for the period 2007-2013. In addition, due to the missing evaluation of the determination of counterions of pharmaceuticals by capillary electromigration methods in the last 20 years, the publications dealing with this topic since 1995 are included in this review. General aspects of both these types of applications of capillary electromigration methods in pharmaceutical analysis are discussed, and detailed experimental conditions used for determination of various chemical impurities and counterions of many particular drugs are described.

引用

页码：2039 / 2055

页数：17

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