Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)

被引：428
作者：
Lee, SL
Sadovsky, Y
Swirnoff, AH
Polish, JA
Goda, P
Gavrilina, G
Milbrandt, J
机构：
[1] WASHINGTON UNIV,SCH MED,DEPT PATHOL,ST LOUIS,MO 63110
[2] WASHINGTON UNIV,SCH MED,DEPT INTERNAL MED,ST LOUIS,MO 63110
[3] WASHINGTON UNIV,SCH MED,DEPT OBSTET & GYNECOL,ST LOUIS,MO 63110
来源：
SCIENCE | 1996年 / 273卷 / 5279期
关键词：
D O I：
10.1126/science.273.5279.1219
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The immediate-early transcription factor NGFl-A (also called Egr-1, zif/268, or Krox-24) is thought to couple extracellular signals to changes in gene expression, Although activins and inhibins regulate follicle-stimulating hormone (FSH) synthesis, no factor has been identified that exclusively regulates luteinizing hormone (LH) synthesis. An analysis of NGFl-A-deficient mice derived from embryonic stem cells demonstrated female infertility that was secondary to LH-beta deficiency. Ovariectomy led to increased amounts of FSH-beta but not LH-beta messenger RNA, which suggested a pituitary defect. A conserved, canonical NGFl-A site in the LH-beta promoter was required for synergistic activation by NGFl-A and steroidogenic factor-1 (SF-1). NGFl-A apparently influences female reproductive capacity through its regulation of LH-beta transcription.
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页码：1219 / 1221
页数：3
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