Extracellular Vesicle-Based Therapeutics in Neurological Disorders

被引：18

作者：

Yuan, Yiwen ^{[1
]}

Sun, Jian ^{[1
]}

You, Tongyao ^{[1
]}

Shen, Weiwei ^{[1
]}

Xu, Wenqing ^{[1
]}

Dong, Qiang ^{[1
,2
,3
]}

Cui, Mei ^{[1
,2
,3
]}

机构：

[1] Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200031, Peoples R China

[2] Fudan Univ, Huashan Hosp, Dept Neurol, State Key Lab Med Neurobiol, Shanghai 200031, Peoples R China

[3] Fudan Univ, Huashan Hosp, MOE Frontiers Ctr Brain Sci, Dept Neurol, Shanghai 200031, Peoples R China

来源：

PHARMACEUTICS | 2022年 / 14卷 / 12期

基金：

中国国家自然科学基金;

关键词：

extracellular vesicles; neurological disorders; mesenchymal stem cells; drug delivery; therapeutics; neurodegenerative diseases; MESENCHYMAL STEM-CELL; EXOSOME-MEDIATED DELIVERY; DRUG-DELIVERY; FUNCTIONAL RECOVERY; CEREBRAL-ISCHEMIA; MESSENGER-RNA; STROMAL CELLS; MOUSE-BRAIN; B-CELLS; STROKE;

D O I：

10.3390/pharmaceutics14122652

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Neurological diseases remain some of the major causes of death and disability in the world. Few types of drugs and insufficient delivery across the blood-brain barrier limit the treatment of neurological disorders. The past two decades have seen the rapid development of extracellular vesicle-based therapeutics in many fields. As the physiological and pathophysiological roles of extracellular vesicles are recognized in neurological diseases, they have become promising therapeutics and targets for therapeutic interventions. Moreover, advanced nanomedicine technologies have explored the potential of extracellular vesicles as drug delivery systems in neurological diseases. In this review, we discussed the preclinical strategies for extracellular vesicle-based therapeutics in neurological disorders and the struggles involved in their clinical application.

引用

页数：15

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