A fluorescent probe to detect thiol-containing amino acids in solid tumors
被引:42
作者:
Ren, Wen Xiu
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Korea Univ, Dept Chem, Seoul 136701, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Ren, Wen Xiu
[1
]
Han, Jiyou
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Korea Univ, Coll Life Sci & Biotechnol, Lab Stem Cells & Tissue Regenerat, Div Biotechnol, Seoul 136713, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Han, Jiyou
[2
]
Pradhan, Tuhin
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Korea Univ, Dept Chem, Seoul 136701, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Pradhan, Tuhin
[1
]
Lim, Ja-Yun
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Korea Univ, Coll Life Sci & Biotechnol, Lab Stem Cells & Tissue Regenerat, Div Biotechnol, Seoul 136713, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Lim, Ja-Yun
[2
]
Lee, Jae Hong
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Korea Univ, Dept Chem, Seoul 136701, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Lee, Jae Hong
[1
]
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Lee, Jaehun
[2
]
Kim, Jong-Hoon
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Korea Univ, Coll Life Sci & Biotechnol, Lab Stem Cells & Tissue Regenerat, Div Biotechnol, Seoul 136713, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Kim, Jong-Hoon
[2
]
Kim, Jong Seung
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Korea Univ, Dept Chem, Seoul 136701, South KoreaKorea Univ, Dept Chem, Seoul 136701, South Korea
Kim, Jong Seung
[1
]
机构:
[1] Korea Univ, Dept Chem, Seoul 136701, South Korea
[2] Korea Univ, Coll Life Sci & Biotechnol, Lab Stem Cells & Tissue Regenerat, Div Biotechnol, Seoul 136713, South Korea
Early detecting of cancer is critical to provide proper treatment and to improve survival of patients. Here, we reported a highly sensitive ratiometric (yellow emission (550 nm) to blue emission (496 nm)) fluorescent probe 1 developed for detection of thiol-containing amino acids. This probe successfully eliminates interference from background autofluorescence, and discriminates between human carcinoma and normal cells by detecting intracellular thiol levels in living cells (P < 0.05), Furthermore, the ability of the probe to identify growing tumors by measuring GSH in the tissues as well as in the fresh blood of tumor xenograft mice. Additionally, the ratio of the emission intensity at two different wavelengths can provide quantitative analysis of glutathione (GSH) in the living systems. It suggests that it represents a promising prognostic and diagnostic marker, with extensive and simple potential clinical applications. (c) 2014 Elsevier Ltd. All rights reserved.
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Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, NetherlandsLeiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, Netherlands
Burg, D
Mulder, GJ
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Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, NetherlandsLeiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, Netherlands
机构:
Ewha Womans Univ, Dept Chem & Nano Sci BK 21, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
Chen, Xiaoqiang
Zhou, Ying
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Ewha Womans Univ, Dept Chem & Nano Sci BK 21, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
Zhou, Ying
Peng, Xiaojun
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Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R ChinaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
Peng, Xiaojun
Yoon, Juyoung
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Ewha Womans Univ, Dept Chem & Nano Sci BK 21, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
机构:
Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
Chen, Xiaoqiang
Ko, Sung-Kyun
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Yonsei Univ, Dept Chem, Seoul 120749, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
Ko, Sung-Kyun
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机构:
Kim, Min Jung
Shin, Injae
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Yonsei Univ, Dept Chem, Seoul 120749, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
Shin, Injae
Yoon, Juyoung
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h-index: 0
机构:
Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Eliane, Jean-Pierre
Repollet, Madeline
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机构:
Immunicon Corp, Huntingdon Valley, PA USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Repollet, Madeline
Luker, Kathryn E.
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Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Luker, Kathryn E.
Brown, Martha
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机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Brown, Martha
Rae, James M.
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机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Rae, James M.
Dontu, Gabriela
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机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Dontu, Gabriela
Schott, Anne F.
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机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Schott, Anne F.
Wicha, Max
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机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Wicha, Max
Doyle, Gerald V.
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机构:
Immunicon Corp, Huntingdon Valley, PA USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Doyle, Gerald V.
Hayes, Daniel F.
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Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Hayes, Daniel F.
Luker, Gary D.
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机构:
Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
机构:
Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, NetherlandsLeiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, Netherlands
Burg, D
Mulder, GJ
论文数: 0引用数: 0
h-index: 0
机构:
Leiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, NetherlandsLeiden Univ, Leiden Amsterdam Ctr Drug Res, Div Toxicol, NL-2333 CC Leiden, Netherlands
机构:
Ewha Womans Univ, Dept Chem & Nano Sci BK 21, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
Chen, Xiaoqiang
Zhou, Ying
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Chem & Nano Sci BK 21, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
Zhou, Ying
Peng, Xiaojun
论文数: 0引用数: 0
h-index: 0
机构:
Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R ChinaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
Peng, Xiaojun
Yoon, Juyoung
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Chem & Nano Sci BK 21, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaDalian Univ Technol, State Key Lab Fine Chem, Dalian 116012, Peoples R China
机构:
Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
Chen, Xiaoqiang
Ko, Sung-Kyun
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Chem, Seoul 120749, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
Ko, Sung-Kyun
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机构:
Kim, Min Jung
Shin, Injae
论文数: 0引用数: 0
h-index: 0
机构:
Yonsei Univ, Dept Chem, Seoul 120749, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
Shin, Injae
Yoon, Juyoung
论文数: 0引用数: 0
h-index: 0
机构:
Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea
Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South KoreaYonsei Univ, Dept Chem, Seoul 120749, South Korea
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Eliane, Jean-Pierre
Repollet, Madeline
论文数: 0引用数: 0
h-index: 0
机构:
Immunicon Corp, Huntingdon Valley, PA USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Repollet, Madeline
Luker, Kathryn E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Luker, Kathryn E.
Brown, Martha
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Brown, Martha
Rae, James M.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Rae, James M.
Dontu, Gabriela
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Dontu, Gabriela
Schott, Anne F.
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Schott, Anne F.
Wicha, Max
论文数: 0引用数: 0
h-index: 0
机构:Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Wicha, Max
Doyle, Gerald V.
论文数: 0引用数: 0
h-index: 0
机构:
Immunicon Corp, Huntingdon Valley, PA USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Doyle, Gerald V.
Hayes, Daniel F.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA
Hayes, Daniel F.
Luker, Gary D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Michigan, Sch Med, Dept Radiol, Ann Arbor, MI 48109 USA
Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USAUniv Michigan, Ctr Comprehens Canc, Breast Oncol Program, Dept Internal Med,Med Sch,Canc Ctr 6312, Ann Arbor, MI 48109 USA