Synthesis, spectroscopic characterization and antiproliferative activity of two platinum(II) complexes containing N-donor heterocycles

被引：20
作者：
Rubino, S. [1 ]
Di Stefano, V. [1 ]
Attanzio, A. [1 ]
Tesoriere, L. [1 ]
Girasolo, M. A. [1 ]
Nicolo, F. [2 ]
Bruno, G. [2 ]
Orecchio, S. [1 ]
Stocco, G. C. [1 ]
机构：
[1] Univ Palermo, Dipartimento Sci & Tecnol Biol Chim & Farmaceut S, I-90128 Palermo, Italy
[2] Univ Messina, Dipartimento Chim Inorgan Chim Analit & Chim Fis, I-98166 Messina, Italy
来源：
INORGANICA CHIMICA ACTA | 2014年 / 418卷
关键词：
Mononuclear platinum complexes; Heterocyclic nitrogen; Dimethylsulfoxide; Antitumor activity; X-RAY-STRUCTURE; METAL-COMPLEXES; PALLADIUM(II) COMPLEXES; MOLECULAR-STRUCTURES; SULFOXIDE COMPLEXES; DIMETHYL-SULFOXIDE; ANTITUMOR-ACTIVITY; IN-VITRO; LIGANDS; CRYSTAL;
D O I：
10.1016/j.ica.2014.03.028
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Novel mononuclear complexes of Pt(II), cis-[PtCl2(DMSO) HL]center dot 2DMSO (1), where HL = 7-amino-2-(methylthio)[1,2,4]triazolo[1,5-a] pyrimidine-6-carboxylic acid and Pt(bdt)Cl-2 (2), where bdt = [2,4-bis(5,6-diphenyl-1,2,4-triazin-3yl)-pyridine] have been synthesized and characterized by elemental analysis, IR and H-1 NMR spectroscopy and X-ray crystallography diffraction analyses. The molecular structure of (1) shows that Pt(II) ion has a square planar geometry with N(3) bonded heterocycle ligand, two cis chloride anions and S-bonded dimethylsulfoxide. The antiproliferative activity of complexes (1) and (2) has been tested in vitro against HepG2 human hepatoma cells and non-malignant human-derived hepatic cells (Chang). Complex (1), cis-[PtCl2(DMSO) HL]center dot 2DMSO, was effective inducer of apoptotic death on HepG2 cells and its cytotoxic activity was higher than that exerted by cisplatin. Apoptosis effect was associated with externalization of plasma membrane phosphatidylserine. (C) 2014 Elsevier B. V. All rights reserved.
引用
收藏
页码：112 / 118
页数：7
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