Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa

被引：48
作者：
Coutelis, Jean-Baptiste [1 ,2 ,3 ]
Gonzalez-Morales, Nicanor [1 ,2 ,3 ]
Geminard, Charles [1 ,2 ,3 ]
Noselli, Stephane [1 ,2 ,3 ]
机构：
[1] Univ Nice Sophia Antipolis, Inst Biol Valrose, F-06189 Nice, France
[2] CNRS, Inst Biol Valrose, UMR 7277, F-06034 Nice, France
[3] Fac Med Nice, INSERM, Inst Biol Valrose, U1091, F-06034 Nice, France
来源：
EMBO REPORTS | 2014年 / 15卷 / 09期
关键词：
L/R asymmetry; symmetry breaking; directional morphogenesis; evolution; invertebrates; vertebrates; LEFT-RIGHT AXIS; PLANAR CELL POLARITY; LEFT-RIGHT SYMMETRY; LEFT-RIGHT DYNEIN; NEURONAL LEFT/RIGHT ASYMMETRY; LEFT-RIGHT ORGANIZER; LEFT-RIGHT REVERSAL; UNCONVENTIONAL MYOSIN; NODAL FLOW; C; ELEGANS;
D O I：
10.15252/embr.201438972
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Differentiating left and right hand sides during embryogenesis represents a major event in body patterning. Left-Right (L/R) asymmetry in bilateria is essential for handed positioning, morphogenesis and ultimately the function of organs (including the brain), with defective L/R asymmetry leading to severe pathologies in human. How and when symmetry is initially broken during embryogenesis remains debated and is a major focus in the field. Work done over the past 20 years, in both vertebrate and invertebrate models, has revealed a number of distinct pathways and mechanisms important for establishing L/R asymmetry and for spreading it to tissues and organs. In this review, we summarize our current knowledge and discuss the diversity of L/R patterning from cells to organs during evolution.
引用
收藏
页码：926 / 937
页数：12
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