Bugs in the system: bringing the human microbiome to bear in cancer immunotherapy

被引：14
作者：
Strouse, Christopher [1 ]
Mangalam, Ashutosh [2 ]
Zhang, Jun [1 ]
机构：
[1] Holden Comprehens Canc Ctr, Dept Internal Med, Div Hematol Oncol & Blood & Marrow Transplantat, Iowa City, IA USA
[2] Univ Iowa, Dept Pathol, Carver Coll Med, Iowa City, IA 52242 USA
来源：
GUT MICROBES | 2019年 / 10卷 / 02期
关键词：
Microbiome; cancer immunotherapy; ANTIBIOTIC USE;
D O I：
10.1080/19490976.2018.1511665
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The influence of the composition of the human microbiome on the efficacy of cancer directed immunotherapies, such as antibodies directed against the programmed cell death 1 protein (PD-1) or its ligand (PD-L1), has garnered increasing attention as the role of immunotherapies in the care of cancer has grown. Dysbiosis (altered microbiota) has recently been reported to adversely affect the efficacy of cancer directed immunotherapies, and correction of this dysbiosis has the potential to improve the efficacy of these treatments. However, the exact mechanisms underlying this relationship remains unknown. Current methods for characterizing the microbiome likely capture only a small portion of the highly complex interaction between the microbiome and the immune system. Here we discuss the recent reports of the influence of dysbiosis on cancer immunotherapy, methods to more fully characterize the interaction between the microbiome and the immune system, and methods of modulating the immune system to improve the efficacy of cancer immunotherapy.
引用
收藏
页码：109 / 112
页数：4
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