Investigation of an XDR-Acinetobacter baumannii ST2 outbreak in an intensive care unit of a Lebanese tertiary care hospital

被引：19

作者：

Osman, Marwan ^{[1
]}

Halimeh, Fatima B. ^{[1
,2
]}

Rafei, Rayane ^{[1
]}

Mallat, Hassan ^{[1
]}

Tom, Jad El ^{[3
]}

Raad, Elie B. ^{[3
]}

Diene, Seydina M. ^{[2
]}

Jamal, Sabah ^{[1
]}

Atrouni, Ahmad Al ^{[1
]}

Dabboussi, Fouad ^{[1
]}

Moudani, Walid ^{[1
]}

Madec, Jean-Yves ^{[4
]}

Saras, Estelle ^{[4
]}

Lupo, Agnese ^{[4
]}

Haenni, Marisa ^{[4
]}

Rolain, Jean-Marc ^{[2
]}

Hamze, Monzer ^{[1
]}

机构：

[1] Lebanese Univ, Fac Publ Hlth, Doctoral Sch Sci & Technol, Lab Microbiol Sante & Environm LMSE, Tripoli, Lebanon

[2] Aix Marseille Univ, Fac Med & Pharm, AP HM, IRD,MEPHI,IHU Mediterranee Infect, 19-21 Blvd Jean Moulin, F-13385 Marseille 05, France

[3] El Youssef Hosp Ctr, Halba, Lebanon

[4] Univ Lyon, ANSES Lab Lyon, Unite Antibioresistance & Virulence Bacteriennes, Lyon, France

来源：

FUTURE MICROBIOLOGY | 2020年 / 15卷 / 16期

关键词：

carbapenem-resistant Acinetobacter baumannii; epidemiology; hospital outbreak; intensive care unit; Lebanon; molecular typing; CARBAPENEM; SPREAD; RESISTANCE; EMERGENCE;

D O I：

10.2217/fmb-2020-0079

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Aim: We sought to investigate the genetic epidemiological relatedness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains of a suspected outbreak in a Lebanese tertiary care hospital to implement necessary infection prevention and control measures. Methods: Twenty-eight nonduplicate CRAB isolates detected among hospitalized patients between January 2016 and July 2017 were studied by real-time polymerase chain reaction (PCR), pulsed-field gel electrophoresis and multilocus sequence typing analyses. Results: Twenty-seven isolates harbored bla(OXA-23). of which one also carried bla(NDM-1). The isolates distributed temporally in two presumably episodes were stratified by pulsed-field gel electrophoresis into many clusters. Although several clones have become endemic in the hospital, we have rapidly implemented appropriate infection prevention and control measures, achieving full eradication from August 2017 to November 2019. Conclusion: We have successfully investigated and controlled a polyclonal outbreak of OXA-23 producing ST2 CRAB.

引用

页码：1535 / 1542

页数：8

共 28 条

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