Chronic kidney disease and the gut microbiome

被引：213

作者：

Hobby, Gerren P. ^{[1
]}

Karaduta, Oleg ^{[3
]}

Dusio, Giuseppina F. ^{[1
]}

Singh, Manisha ^{[1
,2
]}

Zybailov, Boris L. ^{[3
]}

Arthur, John M. ^{[1
,2
]}

机构：

[1] Univ Arkansas Med Sci, Div Nephrol, Little Rock, AR 72211 USA

[2] Cent Arkansas Vet Hlth Syst, Little Rock, AR USA

[3] Univ Arkansas Med Sci, Dept Biochem & Mol Biol, Little Rock, AR 72211 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY | 2019年 / 316卷 / 06期

关键词：

chronic kidney disease; disease progression; gastrointestinal tract; indoxyl sulfate; metaproteomics; microbiome; P-CRESYL SULFATE; CHAIN FATTY-ACIDS; INDOXYL SULFATE; BIFIDOBACTERIUM; EPIDEMIOLOGY; ASSOCIATION; METABOLITES; DIVERSITY; FAILURE; SOLUTES;

D O I：

10.1152/ajprenal.00298.2018

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The gut microbiome is composed of a diverse population of bacteria that have beneficial and adverse effects on human health. The microbiome has recently gained attention and is increasingly noted to play a significant role in health and a number of disease states. Increasing urea concentration during chronic kidney disease (CKD) leads to alterations in the intestinal flora that can increase production of gut-derived toxins and alter the intestinal epithelial harrier. These changes can lead to an acceleration of the process of kidney injury. A number of strategies have been proposed to interrupt this pathway of injury in CKD. The purpose of this review is to summarize the role of the gut microbiome in CKD, tools used to study this microbial population, and attempts to alter its composition for therapeutic purposes.

引用

页码：F1211 / F1217

页数：7

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