Application of Acyzol in the Context of Zinc Deficiency and Perspectives

被引:17
作者
Aliev, Gjumrakch [1 ,2 ,3 ]
Li, Yi [4 ]
Chubarev, Vladimir N. [1 ]
Lebedeva, Svetlana A. [1 ]
Parshina, Lidiya N. [5 ]
Trofimov, Boris A. [5 ]
Sologova, Susanna S. [1 ]
Makhmutova, Alfiya [2 ]
Avila-Rodriguez, Marco F. [6 ]
Klochkov, Sergey G. [2 ]
Galenko-Yaroshevsky, Pavel A. [7 ]
Tarasov, Vadim V. [1 ]
机构
[1] Sechenov First Moscow State Med Univ, Sechenov Univ, Dept Pharmacol & Pharm, 8-2 Trubetskaya St, Moscow 119991, Russia
[2] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka 142432, Russia
[3] GALLY Int Res Inst, 7733 Louis Pasteur Dr 330, San Antonio, TX 78229 USA
[4] Texas A&M Univ, Dept Biol & Hlth Sci, Kingsville, TX 78363 USA
[5] Russian Acad Sci, AE Favorsky Irkutsk Inst Chem, Siberian Branch, 1 Favorsky Str, Irkutsk 664033, Russia
[6] Univ Tolima, Fac Ciencias Salud, Barrio Santa Helena 730006, Ibague, Colombia
[7] Kuban State Med Univ, Dept Pharmacol, Fac Pharm, 4 Sedin St, Krasnodar 350063, Russia
关键词
Acyzol; carbon monoxide; pharmacological activity; zinc; zinc deficiency conditions; TRACE-ELEMENTS; COMMON COLD; NUTRITION; SUPPLEMENTATION; METABOLISM; EXPRESSION; DISCOVERY; PROSTATE; DIARRHEA; SALTS;
D O I
10.3390/ijms20092104
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Zinc is one of the most important essential trace elements. It is involved in more than 300 enzyme systems and is an indispensable participant in many biochemical processes. Zinc deficiency causes a number of disorders in the human body, the main ones being the delay of growth and puberty, immune disorders, and cognitive dysfunctions. There are over two billion people in the world suffering from zinc deficiency conditions. Acyzol, a zinc-containing medicine, developed as an antidote against carbon monoxide poisoning, demonstrates a wide range of pharmacological activities: Anti-inflammatory, reparative, detoxifying, immunomodulatory, bacteriostatic, hepatoprotective, adaptogenic, antioxidant, antihypoxic, and cardioprotective. The presence of zinc in the composition of Acyzol suggests the potential of the drug in the treatment and prevention of zinc deficiency conditions, such as Prasad's disease, immune system pathology, alopecia, allergodermatoses, prostate dysfunction, psoriasis, stomatitis, periodontitis, and delayed mental and physical development in children. Currently, the efficiency of Acyzol in the cases of zinc deficiency is shown in a large number of experimental studies. So, Acyzol can be used as a highly effective drug for pharmacologic therapy of a wide range of diseases and conditions and it opens up new perspectives in the treatment and prevention of zinc deficiency conditions.
引用
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页数:15
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