Effect of Sustained Inflation Length on Establishing Functional Residual Capacity at Birth in Ventilated Premature Rabbits

被引：116

作者：

te Pas, Arjan B. ^{[1
,2
]}

Siew, Melissa ^{[3
]}

Wallace, Megan J. ^{[3
]}

Kitchen, Marcus J. ^{[4
]}

Fouras, Andreas ^{[6
]}

Lewis, Robert A. ^{[5
]}

Yagi, Naoto ^{[7
]}

Uesugi, Kentaro ^{[7
]}

Donath, Susan ^{[8
]}

Davis, Peter G. ^{[2
]}

Morley, Colin J. ^{[2
]}

Hooper, Stuart B. ^{[3
]}

机构：

[1] Leiden Univ, Med Ctr, Dept Pediat, NL-2300 RC Leiden, Netherlands

[2] Royal Womens Hosp, Serv Neonatol, Parkville, Vic 3053, Australia

[3] Monash Univ, Dept Physiol, Melbourne, Vic 3800, Australia

[4] Monash Univ, Sch Phys, Melbourne, Vic 3800, Australia

[5] Monash Univ, Monash Ctr Synchrotron Sci, Melbourne, Vic 3800, Australia

[6] Monash Univ, Div Biol Engn, Melbourne, Vic 3800, Australia

[7] SPring 8 JASRI, Sayo, Hyogo 6795198, Japan

[8] Murdoch Childrens Res Inst, Melbourne, Vic 3052, Australia

来源：

PEDIATRIC RESEARCH | 2009年 / 66卷 / 03期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

DELIVERY ROOM; RESUSCITATION; PRESSURE; VOLUME; PHASE; SURFACTANT; INFANTS; BREATHS;

D O I：

10.1203/PDR.0b013e3181b1bca4

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The effect of inflation length on lung aeration pattern, tidal volumes, and functional residual capacity (FRC) immediately after birth was investigated. Preterm rabbits (28 d), randomized into four groups, received a 1-, 5-, 10-, or 20-s inflation (SI) followed by ventilation with 5 cm H2O end-expiratory pressure. Gas volumes were measured by plethysmography and uniformity of lung aeration by phase contrast x-ray imaging for 7 min. The first inspiratory volume significantly (p < 0.001) increased with inflation duration from a median (IQR) of 0.2 (0.1-3.1) mL/kg for 1-s inflation to 23.4 (19.3-30.4) mL/kg for 20-s SI. The lung was uniformly aerated, and the FRC and tidal volume fully recruited after 20-s SI. A 10-s SI caused a higher FRC (p < 0.05) at 7 min, and a 20-s SI caused a higher FRC (p < 0.05) at 20 s and 7 min than a 1- or 5-s SI. The mean (SD) time for 90% of the lung to aerate was 14.0 (4.1) s using 35 cm H2O peak inflation pressure. In these rabbits, 10- and 20-s SI increased the inspiratory volume and produced a greater FRC, and a 20-s SI uniformly aerated the lung before ventilation started. (Pediatr Res 66: 295-300,2009)

引用

页码：295 / 300

页数：6