Enhanced intraperitoneal delivery of charged, aerosolized curcumin nanoparticles by electrostatic precipitation

被引：5

作者：

Castagna, Arianna ^{[1
]}

Zander, Alexandra J. ^{[2
]}

Sautkin, Iaroslaw ^{[1
]}

Schneider, Marc ^{[2
]}

Shegokar, Ranjita ^{[3
]}

Konigsrainer, Alfred ^{[1
]}

Reymond, Marc Andre ^{[1
]}

机构：

[1] Univ Tubingen, Comprehens Canc Ctr, Dept Gen Visceral & Transplant Surg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany

[2] Saarland Univ, Dept Pharm Biopharmaceut & Pharmaceut Technol, D-66123 Saarbrucken, Germany

[3] Capnomed GmbH, Albring 81, D-78658 Zimmern, Germany

来源：

NANOMEDICINE | 2020年 / 16卷 / 02期

关键词：

curcumin; electromotive drug administration; electrostatic precipitation; intraperitoneal drug delivery; nanoparticles; PIPAC; polylactic-co-glycolic acid (PLGA); zeta potential; PERITONEAL CARCINOMATOSIS; 1ST EVIDENCE; CHEMOTHERAPY;

D O I：

10.2217/nnm-2020-0373

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aims: To investigate the potential of curcumin-loaded polylactic-co-glycolic acid nanoparticles (CUR-PLGA-NPs), alone and with electrostatic precipitation, for improving tissue uptake during pressurized intraperitoneal aerosol chemotherapy (PIPAC). Methods: Positively and negatively charged CUR-PLGA-NPs were delivered as PIPAC into inverted bovine urinary bladders ex vivo. The experiment was repeated with the additional use of electrostatic precipitation pressurized intraperitoneal aerosol chemotherapy (electrostatic PIPAC). Results: Positively charged CUR-PLGA-NPs increased depth of tissue penetration by 81.5% and tissue concentration by 80%. Electrostatic precipitation further improved the uptake of positively charged CUR-PLGA-NPs by 41.8%. Conclusion: The combination of positive charge and electrostatic precipitation have significant potential to improve tissue uptake of nanoparticles during intraperitoneal chemotherapy. [GRAPHICS]

引用

页码：109 / 120

页数：12

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