Glioma EVs Contribute to Immune Privilege in the Brain

被引：24

作者：

Abels, Erik R. ^{[1
,2
,3
]}

Broekman, Marike L. D. ^{[1
,2
,3
,4
,5
]}

Breakefield, Xandra O. ^{[1
,2
,3
]}

Maas, Sybren L. N. ^{[6
,7
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02129 USA

[2] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02129 USA

[3] Harvard Med Sch, NeuroDiscovery Ctr, Boston, MA 02115 USA

[4] Leiden Univ, Med Ctr, Dept Neurosurg, NL-2300 RC Leiden, Netherlands

[5] Haaglanden Med Ctr, Dept Neurosurg, NL-2512 VA The Hague, Netherlands

[6] Univ Med Ctr Utrecht, Dept Neurosurg, UMC Utrecht Brain Ctr, NL-3584 CX Utrecht, Netherlands

[7] Univ Med Ctr Utrecht, Dept Pathol, NL-3584 CX Utrecht, Netherlands

来源：

TRENDS IN CANCER | 2019年 / 5卷 / 07期

关键词：

EXOSOMES;

D O I：

10.1016/j.trecan.2019.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.

引用

页码：393 / 396

页数：5

共 15 条

[1] Intercellular transfer of the oncogenic receptor EGFrvIII by microvesicles derived from tumour cells
Al-Nedawi, Khalid
Meehan, Brian
Micallef, Johann
Lhotak, Vladimir
May, Linda
Guha, Abhijit
Rak, Janusz
[J]. NATURE CELL BIOLOGY, 2008, 10 (05) : 619 - U24
[2] Multidimensional communication in the microenvirons of glioblastoma
Broekman, Marike L.
Maas, Sybren L. N.
Abels, Erik R.
Mempel, Thorsten R.
Krichevsky, Anna M.
Breakefield, Xandra O.
[J]. NATURE REVIEWS NEUROLOGY, 2018, 14 (08) : 482 - 495
[3] Glioblastoma-derived extracellular vesicles modify the phenotype of monocytic cells
de Vrij, Jeroen
Maas, S. L. Niek
Kwappenberg, Kitty M. C.
Schnoor, Rosalie
Kleijn, Anne
Dekker, Lennard
Luider, Theo M.
de Witte, Lot D.
Litjens, Manja
van Strien, Miriam E.
Hol, Elly M.
Kroonen, Jerome
Robe, Pierre A.
Lamfers, Martine L.
Schilham, Marco W.
Broekman, Marike L. D.
[J]. INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (07) : 1630 - 1642
[4] Systemic T Cells Immunosuppression of Glioma Stem Cell-Derived Exosomes Is Mediated by Monocytic Myeloid-Derived Suppressor Cells
Domenis, Rossana
Cesselli, Daniela
Toffoletto, Barbara
Bourkoula, Evgenia
Caponnetto, Federica
Manini, Ivana
Beltrami, Antonio Paolo
Ius, Tamara
Skrap, Miran
Di Loreto, Carla
Gri, Giorgia
[J]. PLOS ONE, 2017, 12 (01):
[5] Proteomic and immunologic analyses of brain tumor exosomes
Graner, Michael W.
Alzate, Oscar
Dechkovskaia, Angelika M.
Keene, Jack D.
Sampson, John H.
Mitchell, Duane A.
Bigner, Darell D.
[J]. FASEB JOURNAL, 2009, 23 (05) : 1541 - 1557
[6] Serum exosomes and cytokines promote a T-helper cell type 2 environment in the peripheral blood of glioblastoma patients
Harshyne, Larry A.
Nasca, Brian J.
Kenyon, Lawrence C.
Andrews, David W.
Hooper, D. Craig
[J]. NEURO-ONCOLOGY, 2016, 18 (02) : 206 - 215
[7] Glioma-derived extracellular vesicles selectively suppress immune responses
Hellwinkel, Justin E.
Redzic, Jasmina S.
Harland, Tessa A.
Gunaydin, Dicle
Anchordoquy, Thomas J.
Graner, Michael W.
[J]. NEURO-ONCOLOGY, 2016, 18 (04) : 497 - 506
[8] The limited capacity of malignant glioma-derived exosomes to suppress peripheral immune effectors
Iorgulescu, J. Bryan
Ivan, Michael E.
Safaee, Michael
Parsa, Andrew T.
[J]. JOURNAL OF NEUROIMMUNOLOGY, 2016, 290 : 103 - 108
[9] Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
Lai, Charles P.
Kim, Edward Y.
Badr, Christian E.
Weissleder, Ralph
Mempel, Thorsten R.
Tannous, Bakhos A.
Breakefield, Xandra O.
[J]. NATURE COMMUNICATIONS, 2015, 6
[10] Extracellular Vesicles: Unique Intercellular Delivery Vehicles
Maas, Sybren L. N.
Breakefield, Xandra O.
Weaver, Alissa M.
[J]. TRENDS IN CELL BIOLOGY, 2017, 27 (03) : 172 - 188

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