Glioma EVs Contribute to Immune Privilege in the Brain

被引：25
作者：
Abels, Erik R. [1 ,2 ,3 ]
Broekman, Marike L. D. [1 ,2 ,3 ,4 ,5 ]
Breakefield, Xandra O. [1 ,2 ,3 ]
Maas, Sybren L. N. [6 ,7 ]
机构：
[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02129 USA
[2] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02129 USA
[3] Harvard Med Sch, NeuroDiscovery Ctr, Boston, MA 02115 USA
[4] Leiden Univ, Med Ctr, Dept Neurosurg, NL-2300 RC Leiden, Netherlands
[5] Haaglanden Med Ctr, Dept Neurosurg, NL-2512 VA The Hague, Netherlands
[6] Univ Med Ctr Utrecht, Dept Neurosurg, UMC Utrecht Brain Ctr, NL-3584 CX Utrecht, Netherlands
[7] Univ Med Ctr Utrecht, Dept Pathol, NL-3584 CX Utrecht, Netherlands
来源：
TRENDS IN CANCER | 2019年 / 5卷 / 07期
关键词：
EXOSOMES;
D O I：
10.1016/j.trecan.2019.05.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. Here we discuss the potential EV-mediated mechanisms underlying glioma immune modulation, as well as the technical difficulties in studying these interactions.
引用
收藏
页码：393 / 396
页数：5
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