A Simple and Convenient One-Pot Synthesis of Benzimidazole Derivatives Using Cobalt(II) Chloride Hexahydrate as Catalyst

被引：86

作者：

Khan, Abu T. ^{[1
]}

Parvin, Tasneem ^{[1
]}

Choudhury, Lokman H. ^{[2
]}

机构：

[1] Indian Inst Technol, Dept Chem, Gauhati 781039, India

[2] NE Hill Univ, Dept Basic Sci & Social Sci, Shillong, Meghalaya, India

来源：

SYNTHETIC COMMUNICATIONS | 2009年 / 39卷 / 13期

关键词：

Aldehydes; benzimidazole; catalysis; cobalt(II) chloride hexahydrate; o-phenylene diamine; EFFICIENT; WATER; TEMPERATURE; LIBRARY; OXIDANT;

D O I：

10.1080/00397910802654815

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method for the convenient synthesis of 2-arylbenzimidazole has been described on reaction with o-phenylenediamine and various aromatic aldehydes using cobalt(II) chloride hexahydrate as a catalyst. The method is cost-effective, high-yielding, clean, and selective.

引用

页码：2339 / 2346

页数：8

共 15 条

[1]

[Anonymous], 2003, TETRAHEDRON LETT, DOI DOI 10.1016/S0040-4039(03)01387-X

[2] Mild and highly efficient method for the synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles [J].

Bahrami, Kiumars ;

Khodaei, M. Mehdi ;

Naali, Fardin .

JOURNAL OF ORGANIC CHEMISTRY, 2008, 73 (17) :6835-6837

[3] A simple and efficient one-pot synthesis of 2-substituted benzimidazoles [J].

Bahrami, Kiumars ;

Khodaei, Mohammad Mehdi ;

Kavianinia, Iman .

SYNTHESIS-STUTTGART, 2007, (04) :547-550

[4] Medical implications of benzimidazole derivatives as drugs designed for targeting DNA and DNA associated processes [J].

Bhattacharya, Santanu ;

Chaudhuri, Padmaparna .

CURRENT MEDICINAL CHEMISTRY, 2008, 15 (18) :1762-1777

[5]

Chi YC, 2000, SYNLETT, P591

[6] Efficient (bromodimethyl)sulfonium bromide mediated synthesis of benzimidazoles [J].

Das, Biswanath ;

Holla, Harish ;

Srinivas, Yallamalla .

TETRAHEDRON LETTERS, 2007, 48 (01) :61-64

[7] A rapid and efficient synthesis of benzimidazoles using hypervalent iodine as oxidant [J].

Du, Li-Hua ;

Wang, Yan-Guang .

SYNTHESIS-STUTTGART, 2007, (05) :675-678

[8] Synthesis of benzimidazoles in high-temperature water [J].

Dudd, LM ;

Venardou, E ;

Garcia-Verdugo, E ;

Licence, P ;

Blake, AJ ;

Wilson, C ;

Poliakoff, M .

GREEN CHEMISTRY, 2003, 5 (02) :187-192

[9] An efficient and one-pot synthesis of imidazolines and benzimidazoles via anaerobic oxidation of carbon-nitrogen bonds in water [J].

Gogol, P ;

Konwar, D .

TETRAHEDRON LETTERS, 2006, 47 (01) :79-82

[10] Synthesis of some new 2-substituted-phenyl-1H-benzimidazole-5-carbonitriles and their potent activity against Candida species [J].

Göker, H ;

Kus, C ;

Boykin, DW ;

Yildiz, S ;

Altanlar, N .

BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (08) :2589-2596

← 1 2 →